Pillion D J, Jenkins R L, Atchison J A, Stockard C R, Clements R S, Grizzle W E
Department of Pharmacology, University of Alabama, Birmingham 35294.
Am J Physiol. 1988 Jun;254(6 Pt 1):E749-55. doi: 10.1152/ajpendo.1988.254.6.E749.
Adult male Fisher rats injected with streptozotocin (Stz) to produce diabetes mellitus demonstrated a significant loss of total body weight associated with adipose and muscle tissue wasting. Paradoxically, intestinal mass and length were increased in Stz-treated rats despite catabolism of other tissues. Concomitant with increased intestinal mass, food and water intake increased significantly in Stz-diabetic animals. Renal weight was not reduced despite the fall in total body weight. It is proposed that the adult Stz-diabetic rat responds to a loss of available insulin by polyphagia, polydipsia, and catabolism of adipose and muscle tissue and that a large percentage of available synthetic fuel is devoted to the production of additional intestinal tissue.
给成年雄性费希尔大鼠注射链脲佐菌素（Stz）以诱发糖尿病，结果显示其体重显著下降，伴有脂肪和肌肉组织消耗。矛盾的是，尽管其他组织发生分解代谢，但经Stz处理的大鼠肠道质量和长度却增加了。与肠道质量增加同时出现的是，Stz诱导的糖尿病动物的食物和水摄入量显著增加。尽管总体重下降，但肾脏重量并未减轻。有人提出，成年Stz诱导的糖尿病大鼠通过多食、多饮以及脂肪和肌肉组织的分解代谢来应对可用胰岛素的缺失，并且很大一部分可用的合成燃料用于生成额外的肠道组织。
