a Department of Cellular and Molecular Nutrition , School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences , Tehran , Iran.
b Students' Research Committee, Isfahan University of Medical Sciences , Isfahan , Iran.
J Am Coll Nutr. 2018 Sep-Oct;37(7):640-649. doi: 10.1080/07315724.2018.1451789. Epub 2018 Apr 20.
Growing evidence suggests beta-hydroxy-beta-methylbutyrate's (HMB) positive effects on recovery following exercise-induced muscle damage (EIMD). However, findings vary substantially across studies.
A meta-analysis of randomized controlled trials was conducted to assess the effects of HMB supplementation on recovery following EIMD by assessing indirect markers of muscle damage, namely creatine kinase (CK) and lactate dehydrogenase (LDH) serum levels among healthy participants.
A comprehensive search was performed on electronic databases (Medline, Scopus, Cochrane Library, and Google Scholar) up to October 2017 for trials evaluating the effects of HMB on recovery following EIMD. Mean ± standard deviation of follow-up CK and LDH concentrations were extracted to calculate the effect size for meta-analysis.
A total of 324 participants for CK and 229 participants for LDH were found from the 10 and 8 studies, respectively. The results revealed a significant effect of HMB supplementation on CK (weighted mean difference [WMD] = -60.71 UL; 95% confidence interval [CI], -78.12 to -43.29; I = 4.1%; p = 0.40) and LDH reduction (WMD = -15.42 UL; 95% CI, -22.2 to -8.6; I = 0.0%; p = 0.53). In addition, a subgroup analysis based on study duration (< 6 weeks vs. ≥ 6 weeks) suggested that HMB effectiveness on EIMD was statistically significant in studies over 6 weeks (p < 0.001).
The current evidence revealed a time-dependent effect of HMB in reducing LDH and CK serum levels among adults. HMB, therefore, may be seen as a priority muscle damage recovery agent in interventions.
越来越多的证据表明β-羟-β-甲基丁酸（HMB）对运动引起的肌肉损伤（EIMD）后的恢复有积极作用。然而，研究结果存在很大差异。
通过评估健康参与者的肌酸激酶（CK）和乳酸脱氢酶（LDH）血清水平等间接肌肉损伤标志物，对 HMB 补充剂在 EIMD 后的恢复效果进行了随机对照试验的荟萃分析。
对电子数据库（Medline、Scopus、Cochrane 图书馆和 Google Scholar）进行了全面检索，检索时间截至 2017 年 10 月，以评估 HMB 对 EIMD 后恢复的影响。提取随访 CK 和 LDH 浓度的均值±标准差，以计算荟萃分析的效应量。
从 10 项和 8 项研究中分别找到了 324 名 CK 参与者和 229 名 LDH 参与者。结果显示，HMB 补充剂对 CK（加权均数差值 [WMD] = -60.71 UL；95%置信区间 [CI]，-78.12 至 -43.29；I = 4.1%；p = 0.40）和 LDH 降低（WMD = -15.42 UL；95% CI，-22.2 至 -8.6；I = 0.0%；p = 0.53）均有显著影响。此外，基于研究持续时间（<6 周与≥6 周）的亚组分析表明，HMB 在 6 周以上的研究中对 EIMD 的有效性具有统计学意义（p<0.001）。
目前的证据表明，HMB 对成年人的 LDH 和 CK 血清水平具有时间依赖性影响。因此，HMB 可能被视为干预中优先考虑的肌肉损伤恢复剂。
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