氮丙啶鎓阳离子与六氢-1,3,5-三嗪的[3+2]-环加成反应：制备 4-咪唑烷酮。
[3 + 2]-Cycloaddition of Azaoxyallyl Cations with Hexahydro-1,3,5-triazines: Access to 4-Imidazolidinones.
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering , Changzhou University , Changzhou 213164 , P. R. China.
出版信息
Org Lett. 2018 May 4;20(9):2745-2748. doi: 10.1021/acs.orglett.8b00951. Epub 2018 Apr 20.
PMID:29676925
Abstract
A novel base-promoted [3 + 2] cycloaddition reaction of azaoxyallyl cations with hexahydro-1,3,5-triazines has been developed, affording 4-imidazolidinones in moderate to good yields under mild reaction conditions. This simple but efficient protocol features cycloaddition of two in situ formed reactive species in the absence of a transition-metal catalyst.
摘要
一种新型的氮杂氧烯鎓离子与六氢-1,3,5-三嗪的[3+2]环加成反应已被开发出来，在温和的反应条件下，以中等至良好的收率得到了 4-咪唑烷酮。该方法简单高效，在没有过渡金属催化剂的情况下，通过两个原位形成的反应性物种的加成反应实现了环加成。
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