Hayakawa R, Arima Y, Hirose O, Takeuchi Y
Division of Dermatology, Nagoya University Branch Hospital, Japan.
Contact Dermatitis. 1988 Apr;18(4):226-8. doi: 10.1111/j.1600-0536.1988.tb02808.x.
Hexamethylenetetramine is an odorless powder and slowly liberates formaldehyde in an acid medium or when heated. It is usually used in the manufacture of formaldehyde resins, rubber and the explosive, cyclonite. It is also used as a hardener in core molding processes. It was reported as one of the formaldehyde releasers and as a cause of formaldehyde contact dermatitis. We report an allergic contact dermatitis due to hexamethylenetetramine, with a positive patch test reaction to hexamethylenetetramine (1% pet.) but not to formaldehyde (2% aq.). We concluded that this case was an allergic contact dermatitis from hexamethylenetetramine itself.
六亚甲基四胺是一种无臭粉末，在酸性介质中或加热时会缓慢释放甲醛。它通常用于制造甲醛树脂、橡胶和炸药黑索今。它也用作型芯成型工艺中的硬化剂。它被报道为一种甲醛释放剂，也是甲醛接触性皮炎的一个病因。我们报告了一例因六亚甲基四胺引起的过敏性接触性皮炎，对六亚甲基四胺（1% 凡士林）斑贴试验反应呈阳性，但对甲醛（2% 水溶液）呈阴性。我们得出结论，该病例是由六亚甲基四胺本身引起的过敏性接触性皮炎。
