Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Campus E8.1, 66123 Saarbrücken, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover-Braunschweig, Germany; Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Helmholtz Institute for Pharmaceutical Research Saarland, Department of Microbial Natural Products, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Campus E8.1, 66123 Saarbrücken, Germany; German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover-Braunschweig, Germany.
Cell Chem Biol. 2018 Apr 19;25(4):351-353. doi: 10.1016/j.chembiol.2018.04.003.
Antimicrobial resistance is increasing at an alarming rate. Polymyxin, one of the few antibiotics of last resort, is heavily affected. In this issue of Cell Chemical Biology, Velkov et al. (2018) present a promising alternative: octapeptin lipopeptide antibiotics active against multidrug- and extensively drug-resistant Gram-negative bacteria, which might help overcoming resistance toward polymyxins.
抗药性正以惊人的速度增长。多粘菌素作为少数几种最后手段的抗生素之一，受到了严重影响。在本期《细胞化学生物学》中，Velkov 等人（2018 年）提出了一个有希望的替代方案：八肽脂肽抗生素，对多药和广泛耐药的革兰氏阴性菌具有活性，这可能有助于克服对抗生素多粘菌素的耐药性。
