Pancré V, Joseph M, Capron A, Wietzerbin J, Kusnierz J P, Vorng H, Auriault C
Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, Lille, France.
Eur J Immunol. 1988 May;18(5):829-32. doi: 10.1002/eji.1830180527.
Human recombinant interferon-gamma (IFN-gamma) significantly increased the expression of receptors for IgE (Fc epsilon RII) on blood platelets. Fc epsilon RII was measured by specific binding of 125I-labeled IgE or flow cytometry experiments. Scatchard analysis of 125I-labeled IgE binding curves revealed that treatment with IFN-gamma increased the number of Fc epsilon RII but did not change the value of the association constant of Fc epsilon RII for 125I-labeled IgE. IFN-alpha had no effect on the expression or affinity of Fc epsilon RII. In addition to Fc epsilon RII, IFN-gamma also modified the expression of the glycoprotein IIb-IIIa complex on the platelet membrane.
人重组干扰素-γ（IFN-γ）显著增加了血小板上IgE受体（FcεRII）的表达。通过125I标记的IgE特异性结合或流式细胞术实验来测定FcεRII。对125I标记的IgE结合曲线进行Scatchard分析表明，用IFN-γ处理可增加FcεRII的数量，但不改变FcεRII对125I标记的IgE的结合常数。IFN-α对FcεRII的表达或亲和力没有影响。除了FcεRII，IFN-γ还改变了血小板膜上糖蛋白IIb-IIIa复合物的表达。
