抗抑郁药物可提高大鼠大脑中神经肽Y（NPY）样免疫反应性的浓度。
Antidepressant drugs increase the concentration of neuropeptide Y (NPY)-like immunoreactivity in the rat brain.
作者信息
Heilig M, Wahlestedt C, Ekman R, Widerlöv E
机构信息
Department of Psychiatry and Neurochemistry, University of Lund, Sweden.
出版信息
Eur J Pharmacol. 1988 Mar 15;147(3):465-7. doi: 10.1016/0014-2999(88)90182-3.
Rats were given imipramine or zimeldine orally for three weeks and the brain levels of neuropeptide Y-like immunoreactivity (NPY-LI) were measured. The concentration of NPY-LI in frontal cortical tissue was elevated by 40 and 60%, respectively. Imipramine increased the concentration of NPY-LI in the hypothalamus by 65% while zimeldine was without effect. The concentration of NPY-LI in the parietal cortex was unaffected by either of the drugs. These observations support the hypothesis that NPY might be involved in the pathophysiology of depressive illness.
给大鼠口服丙咪嗪或齐美利定三周，然后测量大脑中神经肽Y样免疫反应性（NPY-LI）的水平。额叶皮质组织中NPY-LI的浓度分别升高了40%和60%。丙咪嗪使下丘脑NPY-LI的浓度升高了65%，而齐美利定则无此作用。顶叶皮质中NPY-LI的浓度不受这两种药物中任何一种的影响。这些观察结果支持了NPY可能参与抑郁症病理生理学的假说。
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