Department of Chemical and Biological Engineering, University of Sheffield, Newcastle Street, Sheffield S1 3JD, United Kingdom.
Department of Chemical and Biological Engineering, University of Sheffield, Newcastle Street, Sheffield S1 3JD, United Kingdom.
Eur J Pharm Biopharm. 2018 Jul;128:57-68. doi: 10.1016/j.ejpb.2018.04.015. Epub 2018 Apr 17.
In the roller compaction process, powder flow properties have a significant influence on the uniformity of the ribbon properties. The objective of this work was to improve the powder flow in the feeding zone by developing novel feeding guiders which are located in the feeding zone close to the rollers in the roller compactor (side sealing system). Three novel feeding guiders were designed by 3D printing and used in the roller compactor, aiming to control the amount of powder passing across the roller width. The new feeding guiders were used to guide more powder to the sides between the rollers and less powder to the centre comparing to the original feeding elements. Temperature profile and porosity across the ribbon width indicated the uniformity of the ribbon properties. Using the novel feeding guiders resulted in producing ribbons with uniform temperature profile and porosity distribution across the ribbon width. The design of the feeding guiders contributed to improving the tensile strength of the ribbons produced from the compaction stage as well as reducing the fines produced from the crushing stage.
在辊压过程中,粉末流动性能对带状物性能的均匀性有重大影响。本工作的目的是通过开发新型给料导板来改善给料区的粉末流动性能,该给料导板位于辊压机制动器的给料区靠近轧辊处(侧密封系统)。通过 3D 打印设计了三个新型给料导板,并在辊压机制动器中使用,旨在控制穿过轧辊宽度的粉末量。与原始给料元件相比,新型给料导板用于将更多的粉末引导到轧辊之间的两侧,而将更少的粉末引导到轧辊中心。横跨带状物宽度的温度分布和孔隙率表明了带状物性能的均匀性。使用新型给料导板可生产出温度分布和孔隙率分布在整个带状物宽度上均匀的带状物。给料导板的设计有助于提高压实阶段生产的带状物的拉伸强度,并减少破碎阶段产生的细粉。