Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom.
Alexanderwerk AG, Remscheid, North Rhine-Westphalia, 42857, Germany.
Int J Pharm. 2020 Jan 5;573:118815. doi: 10.1016/j.ijpharm.2019.118815. Epub 2019 Nov 18.
Roller compaction is a continuous dry granulation process, where the powder is compressed between two counter-rotating rollers and compacted into ribbons. The quality and homogeneity of the granulate is determined by the uniformity and porosity of the ribbon, which depends on the feeding process of the primary powder to the rollers, the flow properties of the primary powder and process parameters such as roller forces. Previous work was conducted to improve the powder flow and distribution in the feeding zone by developing new feeding guiders, which are located in the feeding zone close to the rollers on the lab-scale roller compactor Alexanderwerk WP120 Pharma (Yu et al., 2018). These new feeding guiders were used to reduce the amount of powder that is delivered to the centre of the rollers and increase the amount of powder that is delivered to the sides of the rollers, in comparison to the original feeding guiders. This modified concept using new feeding guiders has been applied to the large-scale roller compactor Alexanderwerk WP200 Pharma in the present work. In order to evaluate the homogeneity of the ribbon properties across the ribbon width, the temperature profile and porosity distribution across the ribbon width were measured. The new feeding guiders resulted in ribbons being produced with a more uniform temperature profile and porosity distribution across the ribbon width when using the small and large scale roller compactors at different process parameters.
辊压是一种连续的干法造粒工艺，其中粉末在两个反向旋转的辊子之间被压缩并压成带状。颗粒的质量和均一性取决于带状物的均匀性和孔隙率，而这又取决于初级粉末向辊子的进料过程、初级粉末的流动特性以及辊子压力等工艺参数。之前的工作通过开发新的进料导板来改善进料区的粉末流动和分布，这些导板位于实验室规模的亚历山大 WP120 制药辊压机（Yu 等人，2018 年）的进料区靠近辊子的位置。与原始的进料导板相比，这些新的进料导板用于减少输送到辊子中心的粉末量，并增加输送到辊子两侧的粉末量。在本工作中，将使用新的进料导板的这种改进概念应用于大型亚历山大 WP200 制药辊压机。为了评估带状物宽度上的带状物性能的均一性，测量了带状物宽度上的温度分布和孔隙率分布。在不同的工艺参数下，使用小和大尺寸的辊压机时，新的进料导板使带状物的温度分布和孔隙率分布在整个带状物宽度上更加均匀。
