胰高血糖素样肽 1 受体信号转导减弱呼吸道合胞病毒诱导的 2 型反应和免疫病理学。
Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.
机构信息
Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn.
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn.
出版信息
J Allergy Clin Immunol. 2018 Aug;142(2):683-687.e12. doi: 10.1016/j.jaci.2018.01.053. Epub 2018 Apr 17.
Abstract
GLP-1R signaling, an emerging anti-inflammatory therapeutic 59 target, 60 attenuated type 2-associated immunopathology in mice infected with a strain of RSV that was 61 isolated from a hospitalized infant with severe lower respiratory tract infection and bronchiolitis.
摘要
GLP-1R 信号通路作为一种新兴的抗炎治疗靶点，可减轻感染 RSV 病毒株的小鼠的 2 型相关免疫病理学损伤，该病毒株是从一名患有严重下呼吸道感染和细支气管炎的住院婴儿中分离出来的。
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