Department of Biomedical Science and Human Oncology, Paediatric Unit, University of Bari, Bari, Italy.
Department of Basic Medical Sciences, Neuroscience and Sense Organs, Section of Human Anatomy and Histology, School of Medicine-University of Bari, Italy.
Diabetes Res Clin Pract. 2018 Jul;141:10-17. doi: 10.1016/j.diabres.2018.03.046. Epub 2018 Apr 19.
Irisin is a new peptide produced mainly by the skeletal muscle playing an important role both in glucose/energy homeostasis and bone metabolism. Childhood type 1 diabetes mellitus (T1DM) is associated with decreased bone mass. We aimed to evaluate irisin levels in TD1M children and their correlation with bone metabolism and glycaemic control.
Ninety-six T1DM subjects (12.2 ± 4 years), 56 on multiple daily injections (MDI), 40 on continuous subcutaneous insulin infusion (CSII), and 34 controls were included in the study. Irisin and bone remodeling markers were quantified in sera from patients and controls. Bone mineral density (BMD) was evaluated by QUS.
Increased irisin levels were found in T1DM patients respect to controls (p < 0.001). With adjustment for age, irisin levels significantly correlated negatively with HbA1c% (r = -0.105, p < 0.001), years of diabetes (r = -0.07, p < 0.04), 25(OH)-Vitamin D (r = -0.175, p < 0.0001), and positively with BTT-Z-score (r = 0.088, p = 0.016), and osteocalcin (r = 0.059, p < 0.04). We detected the highest levels of irisin in CSII patients compared to MDI and controls (p < 0.001 and p < 0.007 respectively).
We demonstrated high irisin levels in T1DM children and the association of highest irisin amounts to a better glycaemic control and bone health in TDM1 subjects on CSII.
鸢尾素主要由骨骼肌产生，是一种新的肽，在葡萄糖/能量稳态和骨代谢中都发挥着重要作用。儿童 1 型糖尿病（T1DM）与骨量减少有关。我们旨在评估 T1DM 儿童的鸢尾素水平及其与骨代谢和血糖控制的相关性。
本研究纳入了 96 名 T1DM 患者（12.2±4 岁），其中 56 名接受多次皮下注射（MDI），40 名接受持续皮下胰岛素输注（CSII），34 名接受控制。从患者和对照者中定量检测血清中的鸢尾素和骨重塑标志物。通过定量超声（QUS）评估骨矿物质密度（BMD）。
与对照组相比，T1DM 患者的鸢尾素水平升高（p<0.001）。在校正年龄后，鸢尾素水平与 HbA1c%（r=-0.105，p<0.001）、糖尿病病程（r=-0.07，p<0.04）、25（OH）-维生素 D（r=-0.175，p<0.0001）呈显著负相关，与 BTT-Z 评分（r=0.088，p=0.016）和骨钙素（r=0.059，p<0.04）呈显著正相关。与 MDI 组和对照组相比，CSII 组患者的鸢尾素水平最高（p<0.001 和 p<0.007）。
我们在 T1DM 儿童中发现了高水平的鸢尾素，并证明了在接受 CSII 治疗的 TDM1 患者中，鸢尾素水平最高与更好的血糖控制和骨健康相关。
