肥胖儿童和青少年血清鸢尾素与人体测量学、代谢和骨骼参数的相关性研究。
The association of serum irisin with anthropometric, metabolic, and bone parameters in obese children and adolescents.
机构信息
Department of Pediatrics, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Pediatrics, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
出版信息
Front Endocrinol (Lausanne). 2024 Jan 25;14:1326851. doi: 10.3389/fendo.2023.1326851. eCollection 2023.
BACKGROUND
Irisin is an adipomyokine secreted by muscle and adipose cells, and it plays a role in glucose, fat, and bone metabolism. This study aimed to determine the correlation of serum irisin levels with anthropometric, metabolic, and bone parameters in obese children and adolescents.
METHODS
This single-center study included 103 Korean children and adolescents: 54 (52.4%) obese participants with a body mass index (BMI) ≥95th percentile and 49 (47.6%) healthy controls with BMI within the 15th to 85th percentile. Various parameters were measured, including fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride and glucose (TyG) index, lipid profile, alkaline phosphatase (ALP), osteocalcin, and 25(OH)-Vitamin D levels. Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DEXA) in 33 healthy subjects.
RESULTS
Serum irisin was significantly higher in the obese group than in the control group (mean 18.1 ± 3.5 vs. 16.2 ± 2.0 ng/mL; = 0.001). Serum irisin level was positively correlated with chronological age ( = 0.28; = 0.004), height SDS ( = 0.24; = 0.02), BMI SDS ( = 0.37; < 0. 001), fasting glucose ( = 0.27; = 0.007), fasting insulin ( = 0.23; = 0.03), HOMA-IR ( = 0.21; = 0.04), osteocalcin ( = 0.27; = 0.006) and negatively correlated with HDL cholesterol ( = -0.29; = 0.005). All these correlations were evident in obese subjects but not in healthy subjects. ALP and 25(OH)-Vitamin D were unrelated to irisin levels. Among 33 healthy subjects, total body-less head (TBLH) BMD Z-score was positively correlated with serum irisin ( = 0.39; = 0.03), osteocalcin ( = 0.40; = 0.02), fasting insulin ( = 0.39; = 0.04), and HOMA-IR ( = 0.38; = 0.047).
CONCLUSION
This study demonstrated an association between irisin levels and glucose, lipid, and bone parameters in children and adolescents. Our findings suggest that irisin has a potential role in metabolic disorders and bone health in obese children and adolescents.
背景
鸢尾素是一种由肌肉和脂肪细胞分泌的脂肪肌因子，它在葡萄糖、脂肪和骨骼代谢中发挥作用。本研究旨在确定肥胖儿童和青少年血清鸢尾素水平与人体测量、代谢和骨骼参数的相关性。
方法
本单中心研究纳入了 103 名韩国儿童和青少年：54 名（52.4%）肥胖参与者的体重指数（BMI）≥95 百分位，49 名（47.6%）健康对照组的 BMI 在 15 到 85 百分位之间。测量了各种参数，包括空腹血糖、空腹胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、三酰甘油和葡萄糖（TyG）指数、血脂谱、碱性磷酸酶（ALP）、骨钙素和 25（OH）-维生素 D 水平。在 33 名健康受试者中使用双能 X 射线吸收法（DEXA）测量骨矿物质密度（BMD）。
结果
肥胖组血清鸢尾素水平明显高于对照组（均值 18.1±3.5 与 16.2±2.0ng/ml； = 0.001）。血清鸢尾素水平与年龄（ = 0.28； = 0.004）、身高 SDS（ = 0.24； = 0.02）、BMI SDS（ = 0.37； < 0. 001）、空腹血糖（ = 0.27； = 0.007）、空腹胰岛素（ = 0.23； = 0.03）、HOMA-IR（ = 0.21； = 0.04）、骨钙素（ = 0.27； = 0.006）呈正相关，与高密度脂蛋白胆固醇（ = -0.29； = 0.005）呈负相关。所有这些相关性在肥胖组中均有体现，但在健康对照组中没有。ALP 和 25（OH）-维生素 D 与鸢尾素水平无关。在 33 名健康受试者中，全身非头部（TBLH）BMD Z 评分与血清鸢尾素（ = 0.39； = 0.03）、骨钙素（ = 0.40； = 0.02）、空腹胰岛素（ = 0.39； = 0.04）和 HOMA-IR（ = 0.38； = 0.047）呈正相关。
结论
本研究表明鸢尾素水平与儿童和青少年的葡萄糖、脂质和骨骼参数之间存在关联。我们的发现表明，鸢尾素在肥胖儿童和青少年的代谢紊乱和骨骼健康中可能发挥作用。
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