Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China.
Harrison School of Pharmacy, Auburn University, Auburn, AL, United states.
Adv Protein Chem Struct Biol. 2018;112:183-220. doi: 10.1016/bs.apcsb.2018.01.004. Epub 2018 Feb 26.
Many therapeutic macromolecules must enter cells to take their action. However, their treatment outcomes are often hampered by their poor transportation into target cells. Therefore, efficient intracellular delivery of these macromolecules is critical for improving their therapeutic efficacy. Cell-penetrating peptide (CPP)-based approaches are one of the most efficient methods for intracellular delivery of macromolecular therapeutics. Nevertheless, poor specificity is a significant concern for systemic administrated CPP-based delivery systems. This chapter will review recent advances in CPP-mediated macromolecule delivery with a focus on various smart strategies which not only enhance the intracellular delivery but also improve the targeting specificity.
许多治疗性大分子必须进入细胞才能发挥作用。然而，它们的治疗效果往往受到向靶细胞输送的效率低下的影响。因此，这些大分子的有效细胞内递呈对于提高其治疗效果至关重要。基于细胞穿透肽 (CPP) 的方法是大分子治疗剂细胞内递呈的最有效方法之一。然而，系统给予的基于 CPP 的递呈系统的一个主要问题是缺乏特异性。本章将综述 CPP 介导的大分子递呈的最新进展，重点介绍各种智能策略，这些策略不仅增强了细胞内递呈，还提高了靶向特异性。
