Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands.
Department of General Practice, University Medical Center Groningen, University of Groningen, The Netherlands.
Eur J Paediatr Neurol. 2018 Jul;22(4):595-601. doi: 10.1016/j.ejpn.2018.03.010. Epub 2018 Mar 30.
To compare physiological age-relatedness between dyskinesia (dystonia/choreoathetosis), dystonia and ataxia rating scale scores in healthy children.
Three movement disorders specialists quantified dyskinetic-like features in healthy children (n = 52; 4-16 years) using the Dyskinesia Impairment Scale (DIS = DIS-choreoathetosis (DIS-C) + DIS-dystonia (DIS-D)). We compared the age-related regression coefficients of the DIS with data processed from previous studies on dystonia and ataxia rating scales (Burke-Fahn-Marsden Movement and Disability Scales (BFMMS and BFMDS) and Scale for Assessment and Rating of Ataxia (SARA), International Cooperative Ataxia Rating Scale (ICARS) and Brief Ataxia Rating Scale (BARS)).
Dyskinetic scores were obtained in 79% (DIS); 65% (DIS-D) and 17% (DIS-C) versus dystonic and ataxic scores in 98% (BFMMS) and 89% (SARA/ICARS/BARS) of the children. Age-related DIS and DIS-D scores (B = -0.90 and 0.77; p < 0.001) were correlated with age-related BFMMS scores (B = -0.49; p < 0.001; r = 0.87; p < 0.001), whereas DIS-C scores were age-independent. Ataxic scores revealed stronger age-related regression coefficients than dyskinetic and dystonic scores (4-8 years; p < 0.05).
In healthy children, comparison between physiological dyskinesia, dystonia and ataxia rating scale scores revealed: 1. inverse age-relatedness for dystonic and ataxic scores, but not for choreoathetotic scores, 2. interrelated dystonic DIS-D and BFMMS scores, 3. the strongest age-related expression by ataxic scores. In healthy children, these physiological movement disorder-like features are interpreted as an expression of the developing underlying motor centres.
比较运动障碍（肌张力障碍/舞蹈徐动症）、肌张力障碍和共济失调评定量表评分在健康儿童中的生理年龄相关性。
三位运动障碍专家使用运动障碍损害量表（DIS=舞蹈徐动症（DIS-C）+肌张力障碍（DIS-D））评估了 52 名健康儿童（4-16 岁）的类似运动障碍特征。我们比较了 DIS 的年龄相关回归系数与先前关于肌张力障碍和共济失调评定量表（Burke-Fahn-Marsden 运动和残疾量表（BFMMS 和 BFMDS）和共济失调评定量表（SARA）、国际合作共济失调评定量表（ICARS）和简短共济失调评定量表（BARS）的数据处理结果。
79%（DIS）、65%（DIS-D）和 17%（DIS-C）的儿童获得了运动障碍评分，而 98%（BFMMS）和 89%（SARA/ICARS/BARS）的儿童获得了肌张力障碍和共济失调评分。与年龄相关的 DIS 和 DIS-D 评分（B=-0.90 和 0.77；p<0.001）与年龄相关的 BFMMS 评分相关（B=-0.49；p<0.001；r=0.87；p<0.001），而 DIS-C 评分与年龄无关。共济失调评分的年龄相关回归系数强于运动障碍和肌张力障碍评分（4-8 岁；p<0.05）。
在健康儿童中，比较生理运动障碍、肌张力障碍和共济失调评定量表评分发现：1. 肌张力障碍和共济失调评分呈负相关，而舞蹈徐动症评分无年龄相关性；2. 相关的 DIS-D 和 BFMMS 评分；3. 共济失调评分的年龄相关性最强。在健康儿童中，这些生理性运动障碍样特征被解释为发育中运动中枢的表达。
