Dockx R, Baeken C, Duprat R, De Vos F, Saunders J H, Polis I, Audenaert K, Peremans K
Department of Psychiatry and Medical Psychology, Ghent Experimental Psychiatry (GHEP) Laboratory, Faculty of Medicine and Health, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Department of Psychiatry and Medical Psychology, Ghent Experimental Psychiatry (GHEP) Laboratory, Faculty of Medicine and Health, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.
Vet J. 2018 Apr;234:66-71. doi: 10.1016/j.tvjl.2018.02.004. Epub 2018 Feb 14.
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for several neuropsychiatric disorders in human beings, but the neurobiological effects of rTMS in dogs have not been investigated to date. A proof of concept study was designed to evaluate the effect of rTMS on cerebral perfusion, measured with single photon emission computed tomography (SPECT), in dogs. An accelerated high frequency (aHF)-rTMS (20Hz) protocol was applied to the canine left frontal cortex. To accurately target this area, eight dogs underwent a 3 Tesla magnetic resonance imaging (MRI) scan before stimulation. The left frontal cortex was subjected to five consecutive aHF-rTMS sessions with a figure-of-eight coil designed for human beings at an intensity of 110% of the motor threshold. The dogs underwent Tc-d,1 hexamethylpropylene amine oxime (HMPAO) SPECT scans 1 week prior to and 1day after the stimulations. Perfusion indices (PIs) were determined semi-quantitatively; aHF-rTMS resulted in significantly increased PIs in the left frontal cortex and the subcortical region, whereas no significant differences were noted for the other regions. Behaviour was not influenced by the stimulation sessions. As has been observed in human beings, aHF-rTMS applied to the left frontal cortex alters regional cerebral perfusion in dogs.
重复经颅磁刺激（rTMS）已被提议作为治疗人类多种神经精神疾病的方法，但迄今为止，rTMS对犬类的神经生物学效应尚未得到研究。一项概念验证研究旨在评估rTMS对犬类脑灌注的影响，采用单光子发射计算机断层扫描（SPECT）进行测量。将加速高频（aHF）-rTMS（20Hz）方案应用于犬类左侧额叶皮质。为了精确靶向该区域，八只犬在刺激前接受了3特斯拉磁共振成像（MRI）扫描。使用专为人类设计的8字形线圈，以运动阈值的110%的强度对左侧额叶皮质进行连续五次aHF-rTMS治疗。在刺激前1周和刺激后1天，对犬进行锝-99m六甲基丙烯胺肟（HMPAO）SPECT扫描。半定量测定灌注指数（PIs）；aHF-rTMS导致左侧额叶皮质和皮质下区域的PIs显著增加，而其他区域未观察到显著差异。行为不受刺激疗程的影响。正如在人类中观察到的那样，应用于左侧额叶皮质的aHF-rTMS会改变犬类的局部脑灌注。
