Xu Yangfeng, Peremans Kathelijne, Courtyn Jan, Audenaert Kurt, Dobbeleir Andre, D'Asseler Yves, Achten Eric, Saunders Jimmy, Baeken Chris
Ghent Experimental Psychiatry (GHEP) Laboratory, Department of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Front Vet Sci. 2022 Feb 24;9:800158. doi: 10.3389/fvets.2022.800158. eCollection 2022.
Repetitive transcranial magnetic stimulation (rTMS) has been proven to be a useful tool for the treatment of several severe neuropsychiatric disorders. Accelerated (a)rTMS protocols may have the potential to result in faster clinical improvements, but the effects of such accelerated paradigms on brain function remain to be elucidated.
This sham-controlled arTMS study aimed to evaluate the immediate and delayed effects of accelerated high frequency rTMS (aHF-rTMS) on glucose metabolism in healthy beagle dogs when applied over the left frontal cortex.
Twenty-four dogs were randomly divided into four unequal groups: five active ( = 8)/ sham ( = 4) stimulation sessions (five sessions in 1 day), 20 active ( = 8)/ sham ( = 4) stimulation sessions (five sessions/ day for 4 days), respectively. [F] FDG PET scans were obtained at baseline, 24 h poststimulation, after 1 and 3 months post the last stimulation session. We explicitly focused on four predefined regions of interest (left/right prefrontal cortex and left/right hippocampus).
One day of active aHF-rTMS- and not sham- significantly increased glucose metabolism 24 h post-active stimulation in the left frontal cortex only. Four days of active aHF-rTMS only resulted in a nearly significant metabolic decrease in the left hippocampus after 1 month.
Like in human psychiatric disorders, active aHF-rTMS in healthy beagles modifies glucose metabolism, although differently immediately or after 1 month post stimulation. aHF-rTMS may be also a valid option to treat mentally disordered dogs.
重复经颅磁刺激（rTMS）已被证明是治疗几种严重神经精神疾病的有效工具。加速（a）rTMS方案可能有潜力带来更快的临床改善，但这种加速模式对脑功能的影响仍有待阐明。
这项假对照aTMS研究旨在评估在健康比格犬的左额叶皮质应用加速高频rTMS（aHF-rTMS）后对葡萄糖代谢的即时和延迟影响。
24只犬被随机分为四个不等组：分别为5次主动（n = 8）/假（n = 4）刺激疗程（1天内进行5次疗程）、20次主动（n = 8）/假（n = 4）刺激疗程（每天5次疗程，共4天）。在基线、刺激后24小时、最后一次刺激疗程后1个月和3个月时进行[F]FDG PET扫描。我们明确关注四个预定义的感兴趣区域（左/右前额叶皮质和左/右海马体）。
仅1天的主动aHF-rTMS（而非假刺激）在主动刺激后24小时仅显著增加了左额叶皮质的葡萄糖代谢。4天的主动aHF-rTMS仅在1个月后导致左海马体代谢近乎显著下降。
与人类精神疾病一样，健康比格犬中的主动aHF-rTMS会改变葡萄糖代谢，尽管在刺激后立即或1个月后的变化有所不同。aHF-rTMS也可能是治疗患有精神疾病犬只的有效选择。
