Lu Jun, Dong Haoran, Zheng Xuyuan
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, 300070, China.
School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, 300070, China.
Behav Brain Res. 2018 Sep 3;349:130-136. doi: 10.1016/j.bbr.2018.04.013. Epub 2018 Apr 19.
Theta oscillations in medial prefrontal cortex (mPFC) have been consistently implicated in the regulation of anxiety-related behaviors. However, the theta-band functional connectivity in mPFC is less well characterized. Therefore, we simultaneously recorded local filed potentials (LFPs) from mPFC in freely behaving rats in the elevated plus maze (EPM). Functional connectivity among LFPs was measured by directed transfer function (DTF) via spectral Granger causal connectivity analysis. Causal network was then identified based on DTF. Global efficiency (E) was selected to quantitatively describe the characteristic of the network. Our results showed that a significant difference in theta-band functional connectivity between safe and aversive location in the maze anxiety test. Strikingly, DTF and E were higher specifically in the closed arms and decreased sharply prior to entrying into the open arms. These results indicate strengthened theta-band functional connectivity may be related to anxiety.
内侧前额叶皮质（mPFC）中的θ振荡一直被认为与焦虑相关行为的调节有关。然而，mPFC中θ频段的功能连接特征尚不明确。因此，我们在高架十字迷宫（EPM）中对自由活动大鼠的mPFC进行了局部场电位（LFP）同步记录。通过频谱格兰杰因果连接分析，利用定向传递函数（DTF）测量LFP之间的功能连接。然后根据DTF确定因果网络。选择全局效率（E）来定量描述网络特征。我们的结果表明，在迷宫焦虑测试中，安全位置和厌恶位置之间的θ频段功能连接存在显著差异。令人惊讶的是，DTF和E在封闭臂中特别高，而在进入开放臂之前急剧下降。这些结果表明，增强的θ频段功能连接可能与焦虑有关。
