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过敏原引起的类似焦虑的行为与内侧前额叶皮层-杏仁核回路的破坏有关。

Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit.

机构信息

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Faculty of Electrical Engineering, Sharif University of Technology, Tehran, Iran.

出版信息

Sci Rep. 2019 Dec 20;9(1):19586. doi: 10.1038/s41598-019-55539-3.

DOI:10.1038/s41598-019-55539-3
PMID:31863052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6925103/
Abstract

Anxiety is prevalent in asthma, and is associated with disease severity and poor quality of life. However, no study to date provides direct experimental evidence for the effect of allergic inflammation on the structure and function of medial prefrontal cortex (mPFC) and amygdala, which are essential regions for modulating anxiety and its behavioral expression. We assessed the impact of ovalbumin (OVA)-induced allergic inflammation on the appearance of anxiety-like behavior, mPFC and amygdala volumes using MRI, and the mPFC-amygdala circuit activity in sensitized rats. Our findings exhibited that the OVA challenge in sensitized rats induced anxiety-like behavior, and led to more activated microglia and astrocytes in the mPFC and amygdala. We also found a negative correlation between anxiety-like behavior and amygdala volume. Moreover, OVA challenge in sensitized rats was associated with increases in mPFC and amygdala activity, elevation of amygdala delta-gamma coupling, and the enhancement of functional connectivity within mPFC-amygdala circuit - accompanied by an inverted direction of information transferred from the amygdala to the mPFC. We indicated that disrupting the dynamic interactions of the mPFC-amygdala circuit may contribute to the induction of anxiety-related behaviors with asthma. These findings could provide new insight to clarify the underlying mechanisms of allergic inflammation-induced psychiatric disorders related to asthma.

摘要

焦虑在哮喘中很常见，与疾病严重程度和生活质量差有关。然而，迄今为止尚无研究提供过敏炎症对调节焦虑及其行为表达的重要区域——内侧前额叶皮层（mPFC）和杏仁核的结构和功能的直接实验证据。我们使用 MRI 评估卵清蛋白（OVA）诱导的过敏炎症对致敏大鼠出现类似焦虑行为、mPFC 和杏仁核体积的影响，以及 mPFC-杏仁核回路活动。我们的研究结果表明，致敏大鼠的 OVA 挑战会引起类似焦虑的行为，并导致 mPFC 和杏仁核中的小胶质细胞和星形胶质细胞更加活跃。我们还发现类似焦虑行为与杏仁核体积之间存在负相关。此外，致敏大鼠的 OVA 挑战与 mPFC 和杏仁核活动增加、杏仁核 delta-gamma 耦合升高以及 mPFC-杏仁核回路内功能连接增强有关——伴随着信息从杏仁核到 mPFC 的传递方向相反。我们表明，破坏 mPFC-杏仁核回路的动态相互作用可能导致哮喘相关焦虑相关行为的发生。这些发现可以为阐明与哮喘相关的过敏炎症引起的精神障碍的潜在机制提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/e16fa773fd2f/41598_2019_55539_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/16ff3c59949b/41598_2019_55539_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/8c28eac96334/41598_2019_55539_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/c9f352fca1ca/41598_2019_55539_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/a5737ee55acc/41598_2019_55539_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/8c471a9bdf1f/41598_2019_55539_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/e16fa773fd2f/41598_2019_55539_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/16ff3c59949b/41598_2019_55539_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/e8d1c4708fe9/41598_2019_55539_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/70266374403c/41598_2019_55539_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/8c28eac96334/41598_2019_55539_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/c9f352fca1ca/41598_2019_55539_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/a5737ee55acc/41598_2019_55539_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/8c471a9bdf1f/41598_2019_55539_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d4f/6925103/e16fa773fd2f/41598_2019_55539_Fig8_HTML.jpg

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2
Protective effect of heart rate variability biofeedback on stress-induced lung function impairment in asthma.心率变异性生物反馈对哮喘患者应激诱导的肺功能损害的保护作用
Respir Physiol Neurobiol. 2019 Apr;262:49-56. doi: 10.1016/j.resp.2019.01.011. Epub 2019 Jan 26.
3
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Basic Clin Neurosci. 2024 May-Jun;15(3):355-366. doi: 10.32598/bcn.2022.4029.1. Epub 2024 May 1.
4
Amygdalar involvement in respiratory dysfunction.杏仁核与呼吸功能障碍的关系。
Front Physiol. 2024 Aug 28;15:1424889. doi: 10.3389/fphys.2024.1424889. eCollection 2024.
5
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6
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9
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