Hadefi Alia, Huberty Vincent, Lemmers Arnaud, Arvanitakis Marianna, Maggs David, Costamagna Guido, Devière Jacques
Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasmus Hospital, Université Libre de Bruxelles, Brussels, Belgium.
Fractyl Laboratories Inc., Lexington, Massachusetts, USA.
Dig Dis. 2018;36(4):322-324. doi: 10.1159/000487078. Epub 2018 Apr 20.
Type 2 diabetes is a pandemic disease with an incidence that has risen steadily over recent decades. Experimental evidence in animals has demonstrated that intestinal bypass surgery of the upper small intestine, particularly the duodenum, has an important role in glucose homoeostasis. Furthermore, Roux-en-Y bypass performed as bariatric surgery has shown to correct hyperglycaemia from the first postoperative days in obese diabetic patients. Therefore, on the basis of these considerations, duodenal mucosal resurfacing was studied in type 2 diabetes patients as a minimally invasive procedure that could offer an alternative treatment for these patients. Further studies, and particularly large controlled trials, are needed to determine the place of this procedure in the treatment of type 2 diabetes as well as other metabolic diseases such as non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.
2型糖尿病是一种大流行疾病，其发病率在近几十年中稳步上升。动物实验证据表明，上段小肠（特别是十二指肠）的肠道旁路手术在葡萄糖稳态中具有重要作用。此外，作为减肥手术进行的Roux-en-Y旁路手术已显示可在肥胖糖尿病患者术后第一天就纠正高血糖。因此，基于这些考虑，对2型糖尿病患者进行了十二指肠黏膜重建研究，这是一种微创程序，可为这些患者提供替代治疗。需要进一步的研究，特别是大型对照试验，以确定该程序在2型糖尿病以及其他代谢性疾病（如非酒精性脂肪性肝病/非酒精性脂肪性肝炎）治疗中的地位。
