Binet Quentin, Dufour Inès, Agneessens Emmanuel, Debongnie Jean-Claude, Aouattah Tarik, Covas Angélique, Coche Jean-Charles, De Koninck Xavier
Division of Gastroenterology, Clinique Saint-Pierre, Avenue Reine Fabiola, 9, 1340, Ottignies, Belgium.
Division of Radiology, Clinique Saint-Pierre, 1340, Ottignies, Belgium.
Clin J Gastroenterol. 2018 Oct;11(5):424-427. doi: 10.1007/s12328-018-0862-4. Epub 2018 Apr 21.
Dietary supplementation of arginine has been used by numerous world-class athletes and professional bodybuilders over the past 30 years. L-Arginine indeed enhances muscular power and general performance via maintaining ATP level. However, L-arginine is also known to induce acute pancreatitis in murine models.
We report the case of young man presenting with upper abdominal pain and increased serum lipase levels. Contrast-enhanced computed tomography confirms a mild acute pancreatitis. Common etiologies have been ruled out and toxicological anamnestic screening reveals the intake of protein powder. This is, to the best of our knowledge, the second case in human of arginine-induced acute pancreatitis.
This case report suggests that every patient presenting with acute pancreatitis without obvious etiology should be evaluated for the intake of toxics other than alcohol, including L-arginine.
在过去30年里,许多世界级运动员和职业健美运动员都使用精氨酸进行膳食补充。L-精氨酸确实通过维持三磷酸腺苷(ATP)水平来增强肌肉力量和整体表现。然而,在小鼠模型中,L-精氨酸也已知会诱发急性胰腺炎。
我们报告了一名年轻男性患者,其出现上腹部疼痛且血清脂肪酶水平升高。增强计算机断层扫描证实为轻度急性胰腺炎。已排除常见病因,毒理学既往史筛查显示其摄入了蛋白粉。据我们所知,这是人类中第二例精氨酸诱发的急性胰腺炎病例。
本病例报告表明,每一位病因不明的急性胰腺炎患者都应评估是否摄入了除酒精以外的毒物,包括L-精氨酸。