Axelsson B, Jacobsson H
Department of Hospital Physics, Karolinska Sjukhuset, Stockholm, Sweden.
Acta Radiol. 1988 May-Jun;29(3):321-5.
A clinical application of a previously developed technique for absolute quantitation of organ uptake of radioactivity is presented. The method, which is based on single photon emission computed tomography involving correction for scattering and attenuation of photons, enables an accurate in vivo determination of the amount of administered activity taken up in a specific organ. The technique was applied to a comparative clinical trial between propanetetraphosphonate and albumin colloid for liver and spleen scintigraphy. The mean uptake of the liver was 73 +/- 9 per cent using propanetetraphosphonate and 63 +/- 10 per cent using albumin colloid. The corresponding figures for the spleen were 6 +/- 3 and 9 +/- 4 per cent, respectively. The activity concentration of the different lobes of the liver, bone marrow and soft tissue was also estimated. Phantom studies showed that the total uptake in the liver could be determined with an accuracy of about 6 per cent. The accuracy of the clinical examinations was estimated to about 10 per cent.
本文介绍了一种先前开发的用于绝对定量放射性药物器官摄取量的技术的临床应用。该方法基于单光子发射计算机断层扫描，并对光子的散射和衰减进行校正，能够在体内准确测定特定器官摄取的给药活度。该技术应用于丙磺舒四膦酸盐和白蛋白胶体用于肝脏和脾脏闪烁显像的比较临床试验。使用丙磺舒四膦酸盐时肝脏的平均摄取率为73±9%，使用白蛋白胶体时为63±10%。脾脏的相应数字分别为6±3%和9±4%。还估计了肝脏不同叶、骨髓和软组织的活度浓度。模型研究表明，肝脏的总摄取量可以精确到约6%。临床检查的准确度估计约为10%。
