Bazgir Afsaneh, Agha Gholizadeh Mehdi, Khosravi Ayyoob, Mansour Samaei Nader
Depaetment of Human Genetics, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran.
Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran.
Middle East J Dig Dis. 2018 Jan;10(1):40-44. doi: 10.15171/mejdd.2017.89. Epub 2018 Jan 10.
BACKGROUND The association between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln gene polymorphism and hepatocellular carcinoma (HCC) has been investigated in several populations. However, the findings are controversial. The aim of this study was to address the association between XRCC1 Arg399Gln polymorphism and HCC in an Iranian population. METHODS We have evaluated the association between XRCC1 Arg399Gln gene polymorphism and HCC in 151 Iranian individuals (50 patients with HCC and 101 healthy matched controls) using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) method. RESULTS Significant association was found for the XRCC1 A allele and HCC [OR = 1.93, 95% CI (1.16 - 3.25), P = 0.0099]. Also, genotype analysis by SNPStats online software showed a significant association between XRCC1 gene polymorphisms and HCC under co-dominant, dominant, and recessive genetic models. CONCLUSION Our study provides evidence that the XRCC1 Arg399Gln polymorphism may be associated with the risk of HCC development in Iranian population.
在多个群体中研究了X射线修复交叉互补基因1（XRCC1）Arg399Gln基因多态性与肝细胞癌（HCC）之间的关联。然而，研究结果存在争议。本研究的目的是探讨伊朗人群中XRCC1 Arg399Gln多态性与HCC之间的关联。方法：我们采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法，评估了151名伊朗个体（50例HCC患者和101名健康匹配对照）中XRCC1 Arg399Gln基因多态性与HCC之间的关联。结果：发现XRCC1 A等位基因与HCC存在显著关联[比值比（OR）=1.93，95%置信区间（CI）（1.16 - 3.25），P = 0.0099]。此外，通过SNPStats在线软件进行的基因型分析表明，在共显性、显性和隐性遗传模型下，XRCC1基因多态性与HCC之间存在显著关联。结论：我们的研究提供了证据，表明XRCC1 Arg399Gln多态性可能与伊朗人群中HCC发生风险相关。
