鼓膜内陷在胆脂瘤发病机制中的作用。
The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis.
机构信息
Hospital of Clinics of Porto Alegre and Department of Ophthalmology and Otorhinolaryngology, Faculty of Medicine, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2400, Porto Alegre, RS, Brazil.
Weill Cornell Medical College, New York, NY, USA.
出版信息
Biomed Res Int. 2018 Feb 21;2018:9817123. doi: 10.1155/2018/9817123. eCollection 2018.
OBJECTIVE
To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE.
METHODS
Videotoscopy of both ears in 432 patients with cholesteatomas classified as posterior epitympanic (PEC), posterior mesotympanic (PMC), two routes, or undetermined. Tympanic membrane (TM) retractions were classified by location and severity and TM perforations according to signs of previous TM retraction.
RESULTS
TM retraction was the most prevalent alteration in the CLE (42.6%). Cholesteatoma was observed in 17.4%. In patients with PEC, the retraction in the CLE was more frequent in the PF (66.7%) than in the PT (1.4%), and in those with two-route cholesteatoma, the retraction in the CLE most frequently involved both the PT and PF (65.6%; < 0.0001).
CONCLUSION
Our results confirm the essential role of TM retraction at least in the earlier phases of cholesteatoma pathogenesis.
目的
分析胆脂瘤患者的对侧耳（CLE），并将患耳胆脂瘤的生长模式与 CLE 的发现相关联。
方法
对 432 例胆脂瘤患者的双耳进行视频耳镜检查，这些患者被分为后鼓室（PEC）、后中鼓室（PMC）、两种途径或未确定类型。鼓膜（TM）回缩根据位置和严重程度进行分类，TM 穿孔根据先前 TM 回缩的迹象进行分类。
结果
TM 回缩是 CLE 最常见的改变（42.6%）。在 CLE 观察到胆脂瘤（17.4%）。在 PEC 患者中，CLE 的回缩在 PF 中更常见（66.7%），而在 PT 中则不太常见（1.4%），而在双途径胆脂瘤患者中，CLE 的回缩最常累及 PT 和 PF（65.6%；<0.0001）。
结论
我们的结果证实了 TM 回缩至少在胆脂瘤发病的早期阶段起着重要作用。
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