Rosito Letícia Petersen Schmidt, da Costa Sady S, Schachern Patricia A, Dornelles Cristina, Cureoglu Sebahatin, Paparella Michael M
Division of Otolaryngology Head and Neck Surgery, Hospital de Clínicas de Porto Alegre, Brasil.
Laryngoscope. 2007 Oct;117(10):1809-14. doi: 10.1097/MLG.0b013e318123ee29.
The objective of this study is to determine the prevalence of the contralateral ear changes in human temporal bones of donors with chronic otitis media.
Transversal.
The temporal bones were examined under light microscopy and then described. Chronic otitis media was defined by the presence of irreversible inflammatory alterations in the middle ear cleft. The contralateral ear was defined as the normal or the less affected ear. To compare the qualitative variables, the chi test was used. Spearman's nonparametric test was used for correlations. P values less than or equal to .05 were considered significant.
We studied 85 pairs of temporal bones. Cholesteatoma was observed in 22.4% of the more damaged ears. The prevalence of contralateral ears with alterations was 91.8%. The main alterations were granulation tissue (81%), effusion (58%), and tympanic membrane retractions (35%). There was a direct and moderately strong correlation between the extent of granulation tissue in the more damaged ear and the contralateral ear (r(s) = 0.345, P = .004). A strong correlation was observed between the extent of cholesteatoma in the more damaged ear and in the contralateral ear (rs = 0.617, P < .001).
We observed a high prevalence of changes in the contralateral ear. There was a direct correlation between the extent of both granulation tissue and cholesteatoma between the two ears, demonstrating that the more extensive the manifestation of these pathologies in the more damaged ear, the greater they will be in the contralateral ear.
本研究的目的是确定患有慢性中耳炎的供体人颞骨中对侧耳的变化发生率。
横断面研究。
对颞骨进行光学显微镜检查，然后进行描述。慢性中耳炎由中耳裂中存在不可逆的炎症改变来定义。对侧耳定义为正常耳或受累较轻的耳。为比较定性变量，使用卡方检验。使用Spearman非参数检验进行相关性分析。P值小于或等于0.05被认为具有统计学意义。
我们研究了85对颞骨。在损伤较重的耳中，22.4%观察到胆脂瘤。对侧耳有改变的发生率为91.8%。主要改变为肉芽组织（81%）、积液（58%）和鼓膜内陷（35%）。损伤较重耳与对侧耳的肉芽组织范围之间存在直接且中等强度的相关性（r(s)=0.345，P=0.004）。在损伤较重耳与对侧耳的胆脂瘤范围之间观察到强相关性（rs=0.617，P<0.001）。
我们观察到对侧耳变化的高发生率。两只耳朵的肉芽组织和胆脂瘤范围之间存在直接相关性，表明这些病变在损伤较重耳中的表现越广泛，在对侧耳中就越严重。
