一名18岁患有46,X,i(X)(q10)的青春期女孩出现卵巢早衰、身材矮小和桥本氏病。
Premature ovarian failure, short stature, and Hashimoto's disease in an 18-year-old adolescent girl with 46, X, i(X)(q10).
作者信息
Hu Xiang, Zhang Qiao, Gao Feng, Chen Lu-Lu
机构信息
a Department of Endocrinology , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China.
b Department of Cardiovascular Surgery , Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , PR China.
出版信息
Gynecol Endocrinol. 2018 Nov;34(11):925-927. doi: 10.1080/09513590.2018.1464137. Epub 2018 Apr 22.
Premature ovarian failure (POF) is a heterogeneous condition affecting girls and women. We detected a previously healthy 18-year-old adolescent girl, presented with amenorrhea over six months, as well as circulating levels of estradiol lower decreased and follicle-stimulating hormone (FSH) increased. She was 138 cm tall. Results of laboratory tests and/or ultrasound investigations showed 46, X, i(X)(q10) karyotype and Hashimoto's disease. This case suggests that pubertal onset and progression, as well as karyotype analysis, should be evaluated in girls with Hashimoto's disease and short stature.
卵巢早衰（POF）是一种影响女孩和女性的异质性疾病。我们检测到一名此前健康的18岁青春期女孩，出现闭经超过6个月，同时循环雌二醇水平降低而促卵泡生成素（FSH）升高。她身高138厘米。实验室检查和/或超声检查结果显示其核型为46,X,i(X)(q10)以及患有桥本氏病。该病例表明，对于患有桥本氏病和身材矮小的女孩，应评估其青春期启动和发育情况以及进行核型分析。
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