Roy A
Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, MD 20892.
J Affect Disord. 1988 May-Jun;14(3):265-70. doi: 10.1016/0165-0327(88)90044-4.
The dexamethasone suppression test was performed in 63 depressed patients and 43 normal controls. Cortisol nonsuppression was found in 47.6% of the depressed patients and 4.6% of the controls. Among depressed patients both age and reported weight loss, but not severity of depression, were significantly related to postdexamethasone plasma cortisol levels. Patients who were cortisol suppressors had experienced significantly more life events before the onset of depression and had significantly higher hostility scores on a personality questionnaire than cortisol nonsuppressors.
对63名抑郁症患者和43名正常对照者进行了地塞米松抑制试验。发现47.6%的抑郁症患者存在皮质醇不被抑制的情况，而对照组中这一比例为4.6%。在抑郁症患者中，年龄和报告的体重减轻与地塞米松给药后血浆皮质醇水平显著相关，但抑郁严重程度与之无关。皮质醇可被抑制的患者在抑郁发作前经历的生活事件显著更多，并且在一份人格问卷上的敌意得分显著高于皮质醇不被抑制的患者。
