Department of Biochemistry, University of Calcutta, Kolkata, West Bengal, India.
IUBMB Life. 2018 Jul;70(7):593-601. doi: 10.1002/iub.1759. Epub 2018 Apr 23.
Invasion of host cell by pathogens induce various intracellular signalling pathways. The host cell through the initiation of these signalling circuits desperately wants to get rid of the pathogen, whereas the pathogen tries to subvert these defence strategies to create an environment for their successful survival. Leishmania spp. is not an exception. Leishmania have to evolve a range of strategic mechanisms to neutralize macrophage defensive arsenals which enable the parasite to replicate within the phagolysosome of infected host. Understanding these signalling mechanisms in detail will not only improve our basic knowledge of host-pathogen interaction but will also help us to develop effective drug targets not only against leishmaniasis but also for many other macrophage associated diseases. © 2018 IUBMB Life, 70(7):593-601, 2018.
病原体入侵宿主细胞会诱导各种细胞内信号通路。宿主细胞通过启动这些信号通路，拼命想要摆脱病原体，而病原体则试图颠覆这些防御策略，为其成功生存创造环境。利什曼原虫也不例外。利什曼原虫必须进化出一系列策略机制来中和巨噬细胞的防御武器，使寄生虫能够在感染宿主的吞噬体溶酶体中复制。详细了解这些信号机制不仅将提高我们对宿主-病原体相互作用的基础知识，还有助于我们开发有效的药物靶点，不仅针对利什曼病，还针对许多其他与巨噬细胞相关的疾病。©2018IUBMBLife，70（7）：593-601，2018。
