Kalos A, Germenis A, Prountzos P, Kitas G D, Kalodiki E, Fertakis A, Balas P
Department of Pathologic Physiology, Faculty of Medicine, School of Health Sciences, University of Athens, Greece.
Int Angiol. 1988 Jan-Mar;7(1):71-4.
Complement activation in the plasma of patients with severe atherosclerosis (arterial occlusive or aneurysmatic disease) was investigated in this study. The effects of angiography and reconstructive arterial surgery (RAS) were also assessed. Atherosclerosis was not found to be associated with systemic complement activation. Angiography resulted in high levels of C3 breakdown products. Surgery caused a significant degree of systemic complement activation in both patients with atherosclerosis and controls. Post-operative levels of C3 breakdown products were significantly higher in atheromatic patients than in controls, most likely due to the insertion of dacron arterial prostheses in the first group.
本研究调查了严重动脉粥样硬化（动脉闭塞性或动脉瘤性疾病）患者血浆中的补体激活情况。还评估了血管造影和动脉重建手术（RAS）的效果。未发现动脉粥样硬化与全身补体激活有关。血管造影导致C3裂解产物水平升高。手术在动脉粥样硬化患者和对照组中均引起显著程度的全身补体激活。动脉粥样硬化患者术后C3裂解产物水平显著高于对照组，这很可能是由于第一组患者植入了涤纶动脉假体。
