Peckham-Gregory Erin C, Montenegro Roberto E, Stevenson David A, Viskochil David H, Scheurer Michael E, Lupo Philip J, Schiffman Joshua D
Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, One Baylor Plaza, MS: BCM305, Houston, TX 77030, United States; Texas Children's Cancer Center, Texas Children's Hospital, Feigin Center, 1102 Bates St, Houston, TX 77030, United States.
Department of Psychiatry and Behavioral Medicine, The University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, WA 98105, United States.
Cancer Epidemiol. 2018 Jun;54:90-94. doi: 10.1016/j.canep.2018.04.005. Epub 2018 Apr 21.
Racial predilection to pediatric cancer exists; however optic pathway glioma (OPG) risk differences by race/ethnicity are undefined. We estimated differences in OPG incidence across racial/ethnic groups in a multi-state cancer surveillance registry in the United States.
OPG data were obtained from the Surveillance, Epidemiology, and End Results (SEER-18) Program, 2000-2014. Race/ethnicity was categorized as: White; Black; Asian; Other; and Latino/a ("Spanish-Hispanic-Latino"). Latino/a included all races, while all other categories excluded those identified as Latino/a. Age-adjusted incidence rates and rate ratios (IRR) with 95% confidence intervals (CIs) were generated in SEER-STAT (v8.3.4).
Data on 709 OPG cases ages 0-19 were abstracted from SEER-18. Minority children experienced lower age-adjusted OPG incidence rates compared to White children (IRR = 0.38, 95% CI: 0.28-0.50; IRR = 0.41, 95% CI: 0.29-0.58; and IRR = 0.39, 95% CI: 0.32-0.48). In subgroup analyses among the highest risk age categories (0-4, 5-9), minority children experienced lower incidence rates compared to White children. Specific patterns for Latinos/as also emerged. Latino/a children ages 0-4 experienced the lowest incidence rates of all racial/ethnic groups compared to Whites (0.24 per 100,000 person-years versus 0.66 per 100,000 person-years, respectively), whereas among those ages 5-9, Black and Asian children experienced the lowest incidence rates (0.08 per 100,000 person-years each).
Incidence of OPGs was highest among White children. This study represents one of the largest to assess differences in OPG susceptibility by race/ethnicity. These findings may inform future studies that seek to evaluate modifying factors for this pediatric tumor including tumorigenesis, treatment, outcome, and long-term late effects.
小儿癌症存在种族倾向；然而，视神经胶质瘤（OPG）在不同种族/族裔间的风险差异尚不明确。我们在美国一个多州癌症监测登记处估算了不同种族/族裔群体中OPG的发病率差异。
OPG数据取自2000 - 2014年监测、流行病学和最终结果（SEER - 18）项目。种族/族裔分为：白人；黑人；亚裔；其他；以及拉丁裔（“西班牙裔 - 拉丁裔”）。拉丁裔包括所有种族，而所有其他类别排除被认定为拉丁裔的人群。在SEER - STAT（v8.3.4）中生成年龄调整发病率及95%置信区间（CI）的发病率比（IRR）。
从SEER - 18中提取了709例0 - 19岁OPG病例的数据。与白人儿童相比，少数族裔儿童的年龄调整OPG发病率较低（IRR = 0.38，95% CI：0.28 - 0.50；IRR = 0.41，95% CI：0.29 - 0.58；IRR = 0.39，95% CI：0.32 - 0.48）。在最高风险年龄组（0 - 4岁、5 - 9岁）的亚组分析中，少数族裔儿童的发病率低于白人儿童。拉丁裔儿童也呈现出特定模式。0 - 4岁的拉丁裔儿童与白人相比，发病率在所有种族/族裔群体中最低（分别为每10万人年0.24例和每10万人年0.66例），而在5 - 9岁儿童中，黑人和亚裔儿童发病率最低（均为每10万人年0.08例）。
OPG发病率在白人儿童中最高。本研究是评估OPG易感性种族/族裔差异的最大规模研究之一。这些发现可能为未来旨在评估该小儿肿瘤的修饰因素（包括肿瘤发生、治疗、结局和长期晚期效应）的研究提供参考。
