Topuz Mustafa, Genç Ömer, Acele Armagan, Koc Mevlüt
Department of Cardiology, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey.
Department of Cardiology, University of Health Sciences, Adana Health Practices and Research Center, Adana, Turkey.
J Electrocardiol. 2018 Jul-Aug;51(4):738-741. doi: 10.1016/j.jelectrocard.2018.02.002. Epub 2018 Feb 13.
Ascending aortic aneurysm (AAA) is one of the major causes of ventricular diastolic dysfunction. Diastolic dysfunction can induce ventricular repolarization dispersion. Nevertheless, myocardial repolarization dispersion is not yet to be fully evaluated in patients with AAA. We aimed to evaluate ventricular repolarization using QT and Tp-Te interval and corrected (c) Tp-Te/QT ratio in patients with AAA.
One hundred-four patients with AAA without coronary artery disease (CAD) served as the aneurysm group and 82 patients having a normal aortic diameter as the control group. All patients underwent transthoracic echocardiography (TTE) for measurements of LV diastolic function and underwent electrocardiography (ECG) to calculate RR, QT, Tp-Te intervals and QT dispersion. Bazett's formula was used to calculate QTc and cTp-Te intervals. cTp-Te/QT ratio was also calculated.
The groups were similar according to basal characteristics. We found left ventricular diastolic properties were impaired and QT dispersion, QTc interval, and both of Tp-Te and cTp-Te intervals were significantly prolonged in the aneurysm group than the control group. There were also significant correlations between TTE and ECG parameters. On multivariate linear regression analysis, indexed ascending aortic dimension (AAoD), LA diameter and E/e' ratio were independent predictors of ventricular repolarization dispersion in AAA patients.
Our study results showed that patients with AAA may have an increased risk for ventricular arrhythmogenesis because of deteriorated the left ventricular diastolic function.
升主动脉瘤（AAA）是导致心室舒张功能障碍的主要原因之一。舒张功能障碍可诱发心室复极离散。然而，AAA患者的心肌复极离散情况尚未得到充分评估。我们旨在使用QT和Tp-Te间期以及校正的（c）Tp-Te/QT比值来评估AAA患者的心室复极情况。
104例无冠状动脉疾病（CAD）的AAA患者作为动脉瘤组，82例主动脉直径正常的患者作为对照组。所有患者均接受经胸超声心动图（TTE）检查以测量左心室舒张功能，并接受心电图（ECG）检查以计算RR、QT、Tp-Te间期和QT离散度。使用Bazett公式计算QTc和cTp-Te间期。同时计算cTp-Te/QT比值。
两组患者的基础特征相似。我们发现动脉瘤组的左心室舒张特性受损，QT离散度、QTc间期以及Tp-Te和cTp-Te间期均显著长于对照组。TTE和ECG参数之间也存在显著相关性。多变量线性回归分析显示，升主动脉内径指数（AAoD）、左心房直径和E/e'比值是AAA患者心室复极离散的独立预测因素。
我们的研究结果表明，AAA患者可能由于左心室舒张功能恶化而增加室性心律失常发生的风险。
