Fenichel P, Grimaldi M, Hieronimus S, Olivero J F, Donzeau A, Benoit B, Fiorentini M, Tran D K, Harter M, Gillet J Y
Centre de Fécondation in vitro, CHU, Nice.
Presse Med. 1988 Apr 23;17(15):719-22.
The quality of ovarian stimulation for in vitro fertilization with or without an LH-RH analogue was investigated in a randomized trial involving 30 women divided into 3 groups. Group I women were treated with the conventional clomiphene citrate-human menopausal gonadotropin combination without LH-RH analogue. Group II women (long regimen) received a slow-release preparation of triptorelin (DTRp6-LH-RH), an LH-RH analogue, and human menopausal gonadotropin. Group II women (short regimen) were given triptorelin with human menopausal gonadotropin. Inhibition of the endogenous luteinizing hormone using triptorelin improved the results of in vitro fertilization in group II and group III women, but the short regimen was distinctly less compelling and less expensive than the long regimen.
在一项随机试验中，对30名女性进行分组，研究了使用或不使用促黄体生成素释放激素（LH-RH）类似物进行体外受精时卵巢刺激的质量。第一组女性接受常规克罗米芬柠檬酸盐-人绝经期促性腺激素联合治疗，不使用LH-RH类似物。第二组女性（长方案）接受促性腺激素释放激素类似物曲普瑞林的缓释制剂（DTRp6-LH-RH）和人绝经期促性腺激素。第三组女性（短方案）接受曲普瑞林与人绝经期促性腺激素联合治疗。使用曲普瑞林抑制内源性促黄体生成素改善了第二组和第三组女性的体外受精结果，但短方案明显不如长方案有效，且成本更低。
