Fecher Roger A, Leader Brittany A, Patil Yash, Butler Randall
Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Am J Case Rep. 2018 Apr 24;19:482-485. doi: 10.12659/ajcr.908252.
BACKGROUND Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5-5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma. CASE REPORT Here, we present a case of tonsillar SmCC that presented as combined SmCC-squamous cell carcinoma in a cervical lymph node, raising the possibility that the SmCC-component represents disease progression. CONCLUSIONS This case lends further support to the importance of HPV in the development of oropharyngeal SmCC and suggests a mechanism of disease progression.
背景 肺外小细胞癌（SmCC）是一种相对罕见的临床实体，仅占小细胞癌的2.5%-5%。最近，有证据表明，高危型人乳头瘤病毒（HPV）可能在口咽小细胞癌中发挥病因学作用，类似于鳞状细胞癌。病例报告 在此，我们报告一例扁桃体小细胞癌病例，该病例在颈部淋巴结表现为小细胞癌-鳞状细胞癌合并，提示小细胞癌成分可能代表疾病进展。结论 该病例进一步支持了HPV在口咽小细胞癌发生中的重要性，并提示了疾病进展机制。
