扁桃体小细胞癌：人乳头瘤病毒的潜在作用

Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus.

作者信息

Fecher Roger A, Leader Brittany A, Patil Yash, Butler Randall

机构信息

Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

出版信息

Am J Case Rep. 2018 Apr 24;19:482-485. doi: 10.12659/ajcr.908252.

DOI:10.12659/ajcr.908252

PMID:29686221

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5937212/

Abstract

BACKGROUND Extrapulmonary small cell carcinoma (SmCC) is a relatively rare clinical entity constituting only 2.5-5% of SmCCs. Recently, evidence has emerged that high-risk types of human papillomavirus (HPV) might play an etiologic role in oropharyngeal SmCC, similar to squamous cell carcinoma. CASE REPORT Here, we present a case of tonsillar SmCC that presented as combined SmCC-squamous cell carcinoma in a cervical lymph node, raising the possibility that the SmCC-component represents disease progression. CONCLUSIONS This case lends further support to the importance of HPV in the development of oropharyngeal SmCC and suggests a mechanism of disease progression.

摘要

背景肺外小细胞癌（SmCC）是一种相对罕见的临床实体，仅占小细胞癌的2.5%-5%。最近，有证据表明，高危型人乳头瘤病毒（HPV）可能在口咽小细胞癌中发挥病因学作用，类似于鳞状细胞癌。病例报告在此，我们报告一例扁桃体小细胞癌病例，该病例在颈部淋巴结表现为小细胞癌-鳞状细胞癌合并，提示小细胞癌成分可能代表疾病进展。结论该病例进一步支持了HPV在口咽小细胞癌发生中的重要性，并提示了疾病进展机制。