Wisner D, Sturm J, Sutter G, Ellendorf B, Nerlich M
Department of Surgery, University of California, Davis, Medical Center, Sacramento 95817.
Surgery. 1988 Jul;104(1):91-7.
Manipulation of arachidonic acid metabolism may be important in the prevention and treatment of the adult respiratory distress syndrome. This study evaluated a thromboxane receptor blocker, BM 13.177, in a sheep endotoxin model. Sheep with chronic lung lymph fistulas were pretreated with the blocker before being given endotoxin. The blocker attenuated the early increase in pulmonary artery pressure usually seen after endotoxin (blocker + endotoxin, 31.0 +/- 14.5 mm Hg; endotoxin alone, 42.1 +/- 9.6 mm Hg). There was no effect on lymph flows during the later (permeability) phase (at 6 hours: blocker + endotoxin, 574 +/- 287% baseline; endotoxin alone, 311 +/- 102% baseline). Administration of the blocker alone increased pulmonary artery pressure, arterial pressure, and central venous pressure and decreased heart rate and cardiac index. Thromboxane receptor blockade presumably has little effect on elements of arachidonic acid metabolism other than thromboxane. Thromboxane appears to be important in the early pulmonary hypertension of the sheep endotoxin model but is relatively unimportant in the development of increased pulmonary capillary permeability.
调节花生四烯酸代谢可能在预防和治疗成人呼吸窘迫综合征中具有重要意义。本研究在绵羊内毒素模型中评估了一种血栓素受体阻滞剂BM 13.177。患有慢性肺淋巴瘘的绵羊在给予内毒素之前先用该阻滞剂进行预处理。该阻滞剂减弱了通常在内毒素注射后出现的肺动脉压早期升高（阻滞剂 + 内毒素组，31.0 +/- 14.5 mmHg；单独内毒素组，42.1 +/- 9.6 mmHg）。在后期（通透性）阶段（6小时时）对淋巴流量没有影响（阻滞剂 + 内毒素组，为基线的574 +/- 287%；单独内毒素组，为基线的311 +/- 102%）。单独给予该阻滞剂会增加肺动脉压、动脉压和中心静脉压，并降低心率和心脏指数。血栓素受体阻断可能对除血栓素外的花生四烯酸代谢成分影响很小。血栓素在绵羊内毒素模型的早期肺动脉高压中似乎很重要，但在肺毛细血管通透性增加的发展中相对不重要。
