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储存溶液、基因治疗和抗增殖剂对内皮功能和大隐静脉移植血管通畅性的影响。

The effect of storage solutions, gene therapy, and antiproliferative agents on endothelial function and saphenous vein graft patency.

作者信息

Ben Ali Walid, Bouhout Ismail, Perrault Louis P

机构信息

Department of Cardiac Surgery, Montreal Heart Institute, Quebec, Canada.

Department of Surgery, Université de Montréal, Quebec, Canada.

出版信息

J Card Surg. 2018 May;33(5):235-242. doi: 10.1111/jocs.13608. Epub 2018 Apr 23.

DOI:10.1111/jocs.13608
PMID:29687489
Abstract

Vein graft failure remains a major concern after coronary artery bypass graft operations, and is initiated by loss of endothelial cell integrity. Preservation of saphenous vein grafts in the optimal solution after meticulous harvesting can limit the endothelial damage. Despite both experimental and clinical results in favor of buffered solutions, normal saline is still the most widely used solution. This review examines the literature to identify the most optimal storage solutions currently available for vein graft preservation.

摘要

静脉移植物失败仍然是冠状动脉旁路移植术后的一个主要问题，并且是由内皮细胞完整性丧失引发的。在精心获取后将大隐静脉移植物保存在最佳溶液中可以限制内皮损伤。尽管实验和临床结果都支持缓冲溶液，但生理盐水仍然是使用最广泛的溶液。这篇综述研究了文献，以确定目前可用于静脉移植物保存的最佳储存溶液。

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The effect of storage solutions, gene therapy, and antiproliferative agents on endothelial function and saphenous vein graft patency.储存溶液、基因治疗和抗增殖剂对内皮功能和大隐静脉移植血管通畅性的影响。
J Card Surg. 2018 May;33(5):235-242. doi: 10.1111/jocs.13608. Epub 2018 Apr 23.
2
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Eur Heart J. 2025 Jan 3;46(1):19-34. doi: 10.1093/eurheartj/ehae654.
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Specific Graft Treatment Solution Enhances Vascular Endothelial Function.特定的移植治疗溶液可增强血管内皮功能。
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Protective Effects of Different Hypothermal Preservation Solutions on Structure and Function of Isolated Rat Arteries.不同低温保存液对分离大鼠血管结构和功能的保护作用。
Curr Med Sci. 2023 Aug;43(4):768-778. doi: 10.1007/s11596-023-2766-x. Epub 2023 Jul 22.
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