亨廷顿舞蹈症：管理亨廷顿舞蹈症的神经精神症状

Huntington's disease: Managing neuropsychiatric symptoms in Huntington's disease.

作者信息

Loi Samantha M, Walterfang Mark, Velakoulis Dennis, Looi Jeffrey Cl

机构信息

Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Department of Psychiatry, University of Melbourne & NorthWestern Mental Health, Parkville, VIC, Australia.

Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Melbourne Neuropsychiatry Centre, University of Melbourne & NorthWestern Mental Health, Parkville, VIC, Australia.

出版信息

Australas Psychiatry. 2018 Aug;26(4):376-380. doi: 10.1177/1039856218766120. Epub 2018 Apr 24.

DOI:10.1177/1039856218766120

PMID:29687724

Abstract

OBJECTIVES

This clinical update review focuses on the management of the neuropsychiatric manifestations of Huntington's disease (HD). The review highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area.

CONCLUSIONS

Neuropsychiatric symptoms may precede the classic motor clinical symptoms of HD (prodromal HD) by decades and cause significant functional impairment. Early recognition and comprehensive non-pharmacological, usually in combination with pharmacological, treatment is essential.

摘要