Loi Samantha M, Walterfang Mark, Velakoulis Dennis, Looi Jeffrey Cl
Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Department of Psychiatry, University of Melbourne & NorthWestern Mental Health, Parkville, VIC, Australia.
Neuropsychiatrist, Neuropsychiatry Unit, Royal Melbourne Hospital, Parkville, VIC, and; Melbourne Neuropsychiatry Centre, University of Melbourne & NorthWestern Mental Health, Parkville, VIC, Australia.
Australas Psychiatry. 2018 Aug;26(4):376-380. doi: 10.1177/1039856218766120. Epub 2018 Apr 24.
This clinical update review focuses on the management of the neuropsychiatric manifestations of Huntington's disease (HD). The review highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area.
Neuropsychiatric symptoms may precede the classic motor clinical symptoms of HD (prodromal HD) by decades and cause significant functional impairment. Early recognition and comprehensive non-pharmacological, usually in combination with pharmacological, treatment is essential.
本临床最新综述聚焦于亨廷顿舞蹈症（HD）神经精神症状的管理。该综述强调了在这一领域有关药物和非药物治疗、潜在疗法以及近期相关研究发现的当前问题。
神经精神症状可能比HD典型的运动临床症状（前驱HD）早出现数十年，并导致严重的功能损害。早期识别以及综合的非药物治疗（通常与药物治疗联合使用）至关重要。
