[Targeting chemotherapy of colorectal cancer by monoclonal antibody conjugated antitumor drug].

Neocarzinostatin (NCS) was conjugated with mouse monoclonal antibody (A7) that specifically reacted with human colorectal carcinomas in vivo and the conjugates (A7-NCS) were administered to patients with colorectal carcinoma. In several cases the size of the metastatic liver tumor was decreased after intraarterial infusion of A7-NCS. No severe adverse effects were observed in any patients who received A7-NCS. These results suggest that missile cancer chemotherapy using monoclonal antibody as a carrier of anticancer drug will be a promising method for use against cancer.