Yamaguchi T, Takahashi T
Dept. of Surgery, Kyoto Prefectural University of Medicine.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-1):1060-4.
Neocarzinostatin (NCS) was conjugated with mouse monoclonal antibody (A7) that specifically reacted with human colorectal carcinomas in vivo and the conjugates (A7-NCS) were administered to patients with colorectal carcinoma. In several cases the size of the metastatic liver tumor was decreased after intraarterial infusion of A7-NCS. No severe adverse effects were observed in any patients who received A7-NCS. These results suggest that missile cancer chemotherapy using monoclonal antibody as a carrier of anticancer drug will be a promising method for use against cancer.
将新制癌菌素（NCS）与在体内与人结肠直肠癌特异性反应的小鼠单克隆抗体（A7）偶联，并将偶联物（A7-NCS）给予结肠癌患者。在几例患者中，经动脉内输注A7-NCS后，转移性肝肿瘤的大小减小。接受A7-NCS的任何患者均未观察到严重不良反应。这些结果表明，使用单克隆抗体作为抗癌药物载体的导弹式癌症化疗将是一种有前景的抗癌方法。
