Miyoshi Masahiro, Komagome Rika, Yamaguchi Hiroki, Ishida Setsuko, Nagano Hideki, Okano Motohiko
Hokkaido Institute of Public Health, North 19 West 12, Kita-ku, Sapporo 060-0819, Japan.
Microbiol Immunol. 2018 Jun;62(6):411-417. doi: 10.1111/1348-0421.12594.
Strains of measles virus of genotypes D5, H1, D4, D8, and B3 were detected among epidemic, endemic, imported and import-associated cases in Hokkaido district, Japan, during 2006-2015. In the present study, their antigenic features were evaluated by determining the complete nucleotide sequences of their hemagglutinin proteins, which are a major target for neutralizing antibodies, and their amino acid sequences deduced. It was found that the hemagglutinin proteins of these strains had several novel amino acid changes in some functional regions. Although these strains have not caused further infections thus far, these antigenic changes should continue to be monitored to maintain their elimination status.
2006年至2015年期间，在日本北海道地区的流行、地方性、输入性和输入关联病例中检测到了基因型为D5、H1、D4、D8和B3的麻疹病毒株。在本研究中，通过测定其血凝素蛋白的完整核苷酸序列及其推导的氨基酸序列，评估了它们的抗原特性，血凝素蛋白是中和抗体的主要靶点。结果发现，这些毒株的血凝素蛋白在一些功能区域有几个新的氨基酸变化。尽管这些毒株迄今为止尚未引起进一步感染，但应继续监测这些抗原变化，以维持其消除状态。
