Steć Anna, Paluch-Oleś Jolanta, Korolczuk Agnieszka, Magdalena Grzebalska Agnieszka, Kozioł-Montewka Maria, Książek Andrzej
Przegl Lek. 2016;73(9):680-3.
Acquired perforating dermatosis (APD) represents a heterogenous group of skin disorders characterized histopathologically by transepithelial elimination (TEE) of dermal structures. APD is manifested clinically as multi-localized, papulo-nodular skin lesions accompanied by a refractory pruritus. APD typically coexists with long-term disorders, most often diabetic kidney disease (DKD). The paper presents a case of a 56-year-old male patient with chronic kidney disease (CKD) and concomitant acquired reactive perforating collagenosis (ARPC), which is a subtype of APD. Etiological theories of ARPC as well as current diagnostic and treatment principles in dermatosis were described. On the basis of the presented case report and the literature review attention was paid to diagnostic difficulties associated with APD. The assumption was made that APD can be an underdiagnosed disease and thus it is not treated correctly. According to the authors’ opinion, this is an important circumstance to popularize the knowledge about APD.
获得性穿通性皮肤病（APD）是一组异质性皮肤疾病，其组织病理学特征为真皮结构的经上皮排除（TEE）。APD临床表为多部位的丘疹结节性皮肤损害，并伴有难治性瘙痒。APD通常与长期疾病共存，最常见的是糖尿病肾病（DKD）。本文报告了一例56岁男性慢性肾脏病（CKD）患者，同时伴有获得性反应性穿通性胶原病（ARPC），后者是APD的一种亚型。文中描述了ARPC的病因学理论以及皮肤病当前的诊断和治疗原则。基于所呈现的病例报告和文献综述，关注了与APD相关的诊断困难。推测APD可能是一种诊断不足的疾病，因此未得到正确治疗。作者认为，这是普及APD相关知识的一个重要情况。
