Smith C D, Pearlmutter F, Szkrybalo M, Katovich M J
Department of Pharmacodynamics, University of Florida, Gainesville 32610.
Clin Exp Hypertens A. 1988;10(4):629-47. doi: 10.3109/10641968809033915.
This study investigated the effects of treatment with desoxycorticosterone acetate and salt (DOCA/NaCl) on blood pressure, aortic vascular vasopressin receptors and in vitro vascular responsiveness in male rats. Four groups of animals were utilized in the study: a control group on normal tap water, a control group drinking a 1% NaCl solution; a DOCA/NaCl-treated group (1% NaCl in the drinking water); and a uninephrectomized (1K) DOCA/NaCl-treated group. DOCA/NaCl treatment for 4 weeks resulted in a significant elevation in blood pressure which was more pronounced in the uninephrectomized animal. The concentration of specific binding sites for vasopressin on the aorta were reduced in both the DOCA/NaCl-treated groups. However, the vascular responsiveness of the aorta to vasopressin was significantly reduced only in the hypertensive, uninephrectomized-DOCA/NaCl-(1K DOCA/NaCl) treated rat. Both the maximal contraction and the sensitivity was reduced in the 1K DOCA/NaCl group. The results of this study would suggest that the vascular alterations to vasopressin are probably post receptor mediated and result from the DOCA/NaCl-induced hypertension.
本研究调查了用醋酸脱氧皮质酮和盐（DOCA/NaCl）处理对雄性大鼠血压、主动脉血管加压素受体及体外血管反应性的影响。研究中使用了四组动物：饮用普通自来水的对照组、饮用1% NaCl溶液的对照组、DOCA/NaCl处理组（饮用水中含1% NaCl）以及单侧肾切除（1K）DOCA/NaCl处理组。DOCA/NaCl处理4周导致血压显著升高，这在单侧肾切除的动物中更为明显。DOCA/NaCl处理组的主动脉上血管加压素特异性结合位点浓度均降低。然而，仅在高血压的单侧肾切除-DOCA/NaCl-（1K DOCA/NaCl）处理大鼠中，主动脉对血管加压素的血管反应性显著降低。1K DOCA/NaCl组的最大收缩和敏感性均降低。本研究结果表明，血管加压素引起的血管改变可能是受体后介导的，并且是由DOCA/NaCl诱导的高血压导致的。
