Romanò Massimo
Centro Universitario Interdipartimentale di Ricerca in Cure Palliative, Università di Milano.
Recenti Prog Med. 2018 Apr;109(4):216-219. doi: 10.1701/2896.29192.
Heart failure (HF) is one of the leading causes of hospitalization in high-income countries and has a profound negative impact on quality of life. In the United States there are more than 900,000 new cases per year and over one million hospital admissions with a primary diagnosis of HF. A prevalence of 6,500,000 cases (2.2% of the population of aged >20 years) was estimated for the US in 2014, in which there were 300,000 related deaths. Although survival has increased, thanks to the pharmacological and non pharmacological therapy, roughly 50% of HF patients die within 5 years of being diagnosed. HF is a chronic, progressive and incurable syndrome characterized by alternating periods of apparent stability and acute exacerbations, with frequent hospitalizations. Patients with HF experience a high level of symptoms and symptom burden over time, particularly at the end of life. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suffer additional symptoms such as pain, depression, gastrointestinal distress, thirst, fatigue and psychological distress. In HF patients the symptom burden is similar to cancer patients, but patients with advanced HF, in comparison to advanced cancer patients, have a greater number of physical symptoms, worse depression status and lower spiritual well-being. There is evidence that HF patients have the same palliative needs as cancer patients, roughly in 40% of cases, but only 20% actually are admitted to hospice programs in US. This situation seems to be the consequence of cultural gap between guidelines, addressing palliative care and HF, and clinical practice. Bridging this gap is a priority to implement an holistic approach to advanced HF.
心力衰竭(HF)是高收入国家住院治疗的主要原因之一,对生活质量有深远的负面影响。在美国,每年有超过90万新发病例,超过100万因HF作为主要诊断而住院的病例。2014年美国估计有650万例HF患者(占20岁以上人口的2.2%),其中有30万例相关死亡。尽管由于药物和非药物治疗生存率有所提高,但大约50%的HF患者在确诊后5年内死亡。HF是一种慢性、进行性且无法治愈的综合征,其特征是明显稳定期和急性加重期交替出现,且频繁住院。随着时间的推移,HF患者会经历高水平的症状和症状负担,尤其是在生命末期。除了呼吸困难和水肿等典型症状外,HF患者还经常遭受疼痛、抑郁、胃肠道不适、口渴、疲劳和心理困扰等其他症状。HF患者的症状负担与癌症患者相似,但与晚期癌症患者相比,晚期HF患者有更多的身体症状、更差的抑郁状态和更低的精神幸福感。有证据表明,HF患者与癌症患者有相同的姑息治疗需求,大约40%的病例如此,但在美国只有20%的患者实际进入临终关怀项目。这种情况似乎是指南中关于姑息治疗和HF的内容与临床实践之间文化差距的结果。弥合这一差距是对晚期HF实施整体治疗方法的优先事项。