Sankar Arumugam, Chen I-Cheng, Luo Shun-Yuan
Department of Chemistry, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung City 402, Taiwan.
Department of Chemistry, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung City 402, Taiwan.
Carbohydr Res. 2018 Jun 30;463:1-5. doi: 10.1016/j.carres.2018.04.006. Epub 2018 Apr 13.
A simple and efficient protocol for the synthesis of a sphingosine starting from cost-effective phytosphingosine has been described. Two alternative synthetic pathway have been disclosed based on the use of two different kinds of protective groups for the protection of the amino group in the phytosphingosine. The protected phytosphingosine was subsequently transformed into sphingosine in 5 steps i.e. protection of the amine group, protection of 1,3-diol, leaving group insertion, elimination, and one-pot deprotection.
已描述了一种从经济高效的植物鞘氨醇出发合成鞘氨醇的简单有效方案。基于使用两种不同的保护基团来保护植物鞘氨醇中的氨基，公开了两条替代合成途径。受保护的植物鞘氨醇随后通过5个步骤转化为鞘氨醇，即胺基保护、1,3 -二醇保护、引入离去基团、消除反应和一锅法脱保护。
