Matsushita S, Morimoto C, Schlossman S F, Sasazuki T
Department of Genetics, Kyushu University, Fukuoka, Japan.
Hum Immunol. 1988 May;22(1):1-7. doi: 10.1016/0198-8859(88)90046-8.
The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.
单克隆抗体4B4可阻断T8 + T细胞介导的对日本柳杉花粉抗原（CPAg）的IgE反应抑制作用。对CPAg产生IgE反应的辅助性T细胞表达4B4特异性，而抑制性T细胞则不表达。外周血淋巴细胞（PBL）上的4B4分子是一种异二聚体，在活化的CPAg特异性T4 + T细胞上还检测到另外三条带。它们与HLA分子没有密切关联。因此可以设想，4B4分子不仅是辅助性T细胞的标志物，而且在调节对CPAg的IgE反应的抑制-辅助相互作用中具有重要作用。
