Serrano Ryan M, Darragh Robert K, Parent John J
Pediatric Cardiology,Riley Hospital for Children,Indianapolis,IN,USA.
Cardiol Young. 2018 Jun;28(6):888-889. doi: 10.1017/S1047951118000379. Epub 2018 Apr 25.
For most patients, adenoviruses cause few acute health concerns and are often self-limiting. Patients who are immunocompromised or immunosuppressed, however, are at risk for disseminated adenovirus and suffer high morbidity and mortality, without well-defined treatment options. We report the case of a 9-month-old boy who was successfully treated for disseminated adenovirus infection with intravenous immunoglobulin and cidofovir 3 months post heart transplant, tailored to serum adenoviral load and clinical response. We emphasise the importance of early identification, monitoring, and a potentially novel treatment in the paediatric cardiac transplant population with disseminated adenovirus infection.
对于大多数患者来说，腺病毒很少引起急性健康问题，且通常具有自限性。然而，免疫功能低下或免疫抑制的患者有发生播散性腺病毒感染的风险，会出现高发病率和高死亡率，且没有明确的治疗方案。我们报告了一例9个月大男童的病例，该患儿在心脏移植3个月后因播散性腺病毒感染，通过静脉注射免疫球蛋白和西多福韦成功治愈，治疗方案根据血清腺病毒载量和临床反应进行调整。我们强调了在患有播散性腺病毒感染的小儿心脏移植人群中早期识别、监测以及一种可能的新治疗方法的重要性。
