Yin Zhi-Fa, Wang Si-Ming
Department of Stomatology, The Second People's Hospital of Lianyungang City. Lianyungang 222023,Jiangsu Province, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2017 Dec;26(6):654-657.
To investigate the effect of debridement combined with recombinant human epidermal growth factor (rhEGF) on wound healing, scar formation, serum epidermal growth factor and inflammatory factors in patients with oral and maxillofacial trauma.
Eight-two cases with oral and maxillofacial trauma treated in our hospital (January 2015 to December 2016) were retrospectively analyzed. All patients received routine treatment, 41 received rhEGF besides routine treatment (experimental group), 41 patients received only cosmetic debridement and suturing (control group). The effect, wound healing time of 2 groups were recorded and compared. The serum epidermal growth factor, interleukin -6 (IL-6), tumor necrosis factor alpha (TNF-α) and interleukin -1 (Interleukin-1, IL-1) before and after operation were compared between 2 groups. SPSS16.0 software package was used to analyze the data.
The average wound healing time of the patients in the experimental group was 5.1±1.3 days, and the average wound healing time of patients in the control group was 7.4±1.9 days, the difference between 2 groups was statistically significant (t=6.397, P<0.01). The effective rate of the experimental group was significantly higher than the control group (P<0.05). Before operation, the serum epidermal growth factor, IL-6, TNF-α and IL-1 in 2 groups had no significant differences (P>0.05); 2 days and 5 days after operation, the serum epidermal growth factor level of the experimental group was significantly higher than the control group(P<0.05). The serum IL-6, TNF-α, IL-1 level of the experimental group were significantly lower than the control group(P<0.05).The side effects happened in the experimental group were significantly lower than control group (P<0.05).
Patients with oral and maxillofacial trauma treated by debridement combined with rhEGF can promote wound healing and reduce the degree of inflammation.
探讨清创联合重组人表皮生长因子（rhEGF）对口腔颌面部创伤患者伤口愈合、瘢痕形成、血清表皮生长因子及炎症因子的影响。
回顾性分析2015年1月至2016年12月在我院治疗的82例口腔颌面部创伤患者。所有患者均接受常规治疗，其中41例在常规治疗基础上加用rhEGF（试验组），41例仅行清创美容缝合（对照组）。记录并比较两组的疗效、伤口愈合时间。比较两组手术前后血清表皮生长因子、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）及白细胞介素-1（IL-1）水平。采用SPSS16.0软件包进行数据分析。
试验组患者平均伤口愈合时间为5.1±1.3天，对照组患者平均伤口愈合时间为7.4±1.9天，两组差异有统计学意义（t=6.397，P<0.01）。试验组有效率显著高于对照组（P<0.05）。术前，两组血清表皮生长因子、IL-6、TNF-α及IL-1水平差异无统计学意义（P>0.05）；术后2天及5天，试验组血清表皮生长因子水平显著高于对照组（P<0.05）。试验组血清IL-6、TNF-α、IL-1水平显著低于对照组（P<0.05）。试验组不良反应发生率显著低于对照组（P<0.05）。
清创联合rhEGF治疗口腔颌面部创伤患者可促进伤口愈合，减轻炎症程度。
