Arrigo-Reina R
Institute of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Catania, Italy.
Agents Actions. 1988 Apr;23(3-4):334-6. doi: 10.1007/BF02142580.
The role of mast cell histamine in body reactivity of rats under experimental stressful conditions was studied. Animals submitted to chronic anaphylactoid reactions (by injecting compound 48/80 at the dose of 1 mg/kg, i.p., twice daily, for five days), when exposed to cold-restraint stress, exhibited a fully evident inflammatory response in the carrageenin-oedema test, whereas saline-treated rats, under the same experimental conditions, showed reduced paw oedema. Interestingly, a single injection of compound 48/80 increased the pituitary content of Beta-endorphin(ir), but chronic administration failed to produce this effect suggesting that some adaptation of the organism to repeated anaphylactoid reactions may occur. These results support the hypothesis of correlations between pituitary Beta-endorphin and mast cell histamine in the reactivity of the organism to stressful stimuli.
研究了肥大细胞组胺在实验应激条件下大鼠身体反应性中的作用。接受慢性类过敏反应（通过腹腔注射剂量为1mg/kg的化合物48/80，每日两次，共五天）的动物，在受到冷束缚应激时，在角叉菜胶水肿试验中表现出完全明显的炎症反应，而在相同实验条件下用生理盐水处理的大鼠 paw 水肿减轻。有趣的是，单次注射化合物48/80可增加垂体中β-内啡肽（ir）的含量，但长期给药未能产生这种效果，这表明机体可能会对重复的类过敏反应产生某种适应性。这些结果支持了垂体β-内啡肽与肥大细胞组胺在机体对应激刺激反应性方面存在相关性的假说。
