Experimental Psychology, Helmholtz Institute, Utrecht University, Heidelberglaan 1, 3584 CS, Utrecht, The Netherlands.
Korsakoff Center Slingedael, Lelie Care Group, Rotterdam, The Netherlands.
Obes Surg. 2018 Jul;28(7):2060-2068. doi: 10.1007/s11695-018-3262-4.
Half a million bariatric procedures are performed annually worldwide. Our aim was to review the signs and symptoms of Wernicke's encephalopathy (WE) after bariatric surgery. We included 118 WE cases. Descriptions involved gastric bypass (52%), but also newer procedures like the gastric sleeve. Bariatric WE patients were younger (median = 33 years) than those in a recent meta-analysis of medical procedures (mean = 39.5 years), and often presented with vomiting (87.3%), ataxia (84.7%), altered mental status (76.3%), and eye movement disorder (73.7%). Younger age seemed to protect against mental alterations and higher BMI against eye movement disorders. The WE treatment was often insufficient, specifically ignoring low parenteral thiamine levels (77.2%). In case of suspicion, thiamine levels should be tested and treated adequately with parenteral thiamine supplementation.
全球每年进行五十万例减肥手术。我们的目的是回顾减肥手术后韦尼克脑病 (WE) 的症状和体征。我们纳入了 118 例 WE 病例。描述涉及胃旁路手术(52%),但也包括胃袖状切除术等新手术。减肥 WE 患者比最近一项医学手术的荟萃分析中的患者年轻(中位数=33 岁),且常表现为呕吐(87.3%)、共济失调(84.7%)、意识改变(76.3%)和眼球运动障碍(73.7%)。年轻似乎可以预防精神改变,而较高的 BMI 则可以预防眼球运动障碍。WE 的治疗往往不足,特别是忽视了较低的肠外硫胺素水平(77.2%)。如果怀疑有这种病,应检测硫胺素水平并通过肠外硫胺素补充进行充分治疗。