血清素参与前列腺素D2（PGD2）对去势雄性大鼠促黄体生成素（LH）释放的抑制作用。

Serotonin involvement in the inhibition of luteinizing hormone (LH) release induced by prostaglandin D2 (PGD2) in castrated male rats.

作者信息

Koh T, Nakai Y, Kinoshita F, Imura H

机构信息

Department of Medicine, Kyoto University School of Medicine, Japan.

出版信息

Eur J Pharmacol. 1988 Apr 27;149(1-2):131-5. doi: 10.1016/0014-2999(88)90050-7.

DOI:10.1016/0014-2999(88)90050-7

PMID:2969338

Abstract

p-Chlorophenylalanine (PCPA, 320 mg/kg i.p.), an inhibitor of serotonin (5-HT) synthesis, and 5,6-dihydroxy-tryptamine (5,6-DHT, 50 micrograms i.c.v.), a drug toxic to the indoleaminergic system were used to test the involvement of 5-HT in the mediation of the inhibitory effect of prostaglandin D2 (PGD2) on luteinizing hormone (LH) release in castrated male rats. The i.c.v. administration of PGD2 suppressed the episodic LH release characteristic of castrated rats and decreased mean plasma LH levels and mean LH pulse amplitude significantly. Pretreatment with PCPA or 5,6-DHT apparently eliminated the inhibitory effect of PGD2 on LH secretion. These results suggest the possible involvement of a serotonergic mechanism in the mediation of the suppression of LH secretion induced by PGD2 in castrated male rats.

摘要

对氯苯丙氨酸（PCPA，腹腔注射320毫克/千克），一种血清素（5-羟色胺，5-HT）合成抑制剂，以及5,6-二羟基色胺（5,6-DHT，脑室内注射50微克），一种对吲哚胺能系统有毒性的药物，被用于测试5-羟色胺在介导前列腺素D2（PGD2）对去势雄性大鼠促黄体生成素（LH）释放的抑制作用中的参与情况。脑室内注射PGD2抑制了去势大鼠特有的LH阵发性释放，并显著降低了平均血浆LH水平和平均LH脉冲幅度。用PCPA或5,6-DHT预处理明显消除了PGD2对LH分泌的抑制作用。这些结果表明，在去势雄性大鼠中，5-羟色胺能机制可能参与介导PGD2诱导的LH分泌抑制。