在初级医疗实践中接受治疗的巴勒斯坦人中，糖尿病并发症的临床特征和生化因素的患病率及相关性。

Prevalence and association of clinical characteristics and biochemical factors with complications of diabetes mellitus in Palestinians treated in primary healthcare practice.

作者信息

Shawahna Ramzi, Shanti Yousef, Al Zabadi Hamzeh, Sharabati Mutassem, Alawneh Ammar, Shaqu Rakan, Taha Ibrahim, Bustami Adnan

机构信息

Department of Physiology, Pharmacology, and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine; An-Najah BioSciences Unit, Centre for Poisons Control, Chemical and Biological Analyses, An-Najah National University, Nablus, Palestine.

An-Najah National University Hospital, Nablus, Palestine.

出版信息

Diabetes Metab Syndr. 2018 Sep;12(5):693-704. doi: 10.1016/j.dsx.2018.04.024. Epub 2018 Apr 13.

DOI:10.1016/j.dsx.2018.04.024

PMID:29693548

Abstract

AIMS

The current study was carried out to examine prevalence of complications related to diabetes mellitus (DM) and to investigate association between clinical variables and biochemical factors with complications of DM in patients treated in primary healthcare settings in the West Bank of Palestine.

MATERIALS AND METHODS

Sociodemographic, clinical, and biochemical variables were collected from 385 patients visiting 17 primary healthcare settings in the West Bank. Patients provided blood and urine samples, responded to a questionnaire interview, and were subjected to ophthalmic examination.

RESULTS

HbA levels were predicted by duration of DM (p < 0.001), HDL (p = 0.011), alkaline phosphatase (p = 0.001), blood urea (p = 0.006), and LDL (p = 0.008). Triglycerides levels were predicted by blood urea (p = 0.002), HDL (p < 0.001), and total cholesterol (p < 0.001). GOT levels were predicted by LDL (p = 0.002) and GPT (p < 0.001). GPT levels were predicted by HDL (p = 0.003) and blood urea (p = 0.025). Urine albumin were predicted by total cholesterol (p = 0.001), LDL (p = 0.005), and blood urea (p = 0.036). CD ratio was predicted by the IOP and the IOP was predicted by the CD ratio (p = 0.001).

CONCLUSIONS

Prevalence of complications related to DM was high among patients with DM treated in primary healthcare practice. These complications and risk factors were predicted by certain clinical characteristics and biochemical factors. Policies and programs are needed to manage these modifiable risk factors.

摘要

目的

开展本研究以检查与糖尿病（DM）相关并发症的患病率，并调查巴勒斯坦西岸初级卫生保健机构中接受治疗的患者的临床变量和生化因素与DM并发症之间的关联。

材料与方法

收集了来自西岸17家初级卫生保健机构的385名患者的社会人口统计学、临床和生化变量。患者提供了血液和尿液样本，回答了问卷调查，并接受了眼科检查。

结果

糖化血红蛋白（HbA）水平由DM病程（p<0.001）、高密度脂蛋白（HDL，p=0.011）、碱性磷酸酶（p=0.001）、血尿素（p=0.006）和低密度脂蛋白（LDL，p=0.008）预测。甘油三酯水平由血尿素（p=0.002）、HDL（p<0.001）和总胆固醇（p<0.001）预测。谷草转氨酶（GOT）水平由LDL（p=0.002）和谷丙转氨酶（GPT，p<0.001）预测。GPT水平由HDL（p=0.003）和血尿素（p=0.025）预测。尿白蛋白由总胆固醇（p=0.001）、LDL（p=0.005）和血尿素（p=0.036）预测。杯盘比（CD比）由眼压（IOP）预测，而IOP由CD比预测（p=0.001）。