Kong X, Ding L J, Wang Z X
Eur J Gynaecol Oncol. 2017;38(3):350-355.
To detect the expression of mucins in diverse benign and malignant cervical tissues of cervical disease.
158 cases of cervical tissues were collected. Sections were stained with monoclonal antibodies against MUC1, MUC2, MIUC4, MUC5AC, and MUC20 by immunohistochemistry.
Normal cervical epithelium showed high expr ession of MUC1I, MUC4, and MUC5AC, partial expression of MUC20, and no MUC2. With the development from chronic cervicitis, cervical intraepithelial neoplasia (CI7N) to cervical squamous cell carcinoma (SCC), the expression of MUC1, NMUC4, and MUC20 was statistically significant. The expression of MUCl was related with the depth of invasion and clinical stage of SCC. The positive rates of MUC4 and MUC20 were associated with the degree of differentiation and clinical stage of SCC. There was a correlation between the expression of MUC4, MUC 1, and MUC20 in cervical squamous lesions.
Mucins may be involved in the development of cervical cancer.
检测黏蛋白在宫颈疾病各种良性和恶性宫颈组织中的表达情况。
收集158例宫颈组织。采用免疫组织化学方法，用抗MUC1、MUC2、MUC4、MUC5AC和MUC20的单克隆抗体对切片进行染色。
正常宫颈上皮显示MUC1、MUC4和MUC5AC高表达，MUC20部分表达，无MUC2表达。随着从慢性宫颈炎、宫颈上皮内瘤变（CIN）发展到宫颈鳞状细胞癌（SCC），MUC1、MUC4和MUC20的表达有统计学意义。MUC1的表达与SCC的浸润深度和临床分期有关。MUC4和MUC20的阳性率与SCC的分化程度和临床分期有关。宫颈鳞状病变中MUC4、MUC1和MUC20的表达之间存在相关性。
黏蛋白可能参与宫颈癌的发生发展。
