多巴胺D1和D2受体在6-羟基多巴胺损伤大鼠中多巴胺激动剂诱导的转向行为中的相互作用。

Dopamine D1- and D2-receptor interaction in turning behaviour induced by dopamine agonists in 6-hydroxydopamine-lesioned rats.

作者信息

Karlsson G, Jaton A L, Vigouret J M

机构信息

Preclinical Research, Sandoz Ltd., Basel, Switzerland.

出版信息

Neurosci Lett. 1988 May 16;88(1):69-74. doi: 10.1016/0304-3940(88)90317-5.

DOI:10.1016/0304-3940(88)90317-5

PMID:2969468

Abstract

The selective dopamine D2-antagonist sulpiride potentiated contralateral circling behaviour induced by the D1-agonist CY 208-243 in rats with unilateral lesions of substantia nigra, but reduced the effects of the selective D2-agonist bromocriptine. Similarly, the D1-antagonist SCH 23390 tended to increase the effects of bromocriptine but markedly inhibited CY 208-243 induced turning. The mixed D1/D2-antagonist fluphenazine was effective in reducing circling behaviour induced by either agonist, whereas pimozide (D1/D2) inhibited only the actions of bromocriptine. These results indicate that the actions of CY 208-243 and bromocriptine are mediated via distinct but interacting receptor subtypes.

摘要

选择性多巴胺D2拮抗剂舒必利增强了由D1激动剂CY 208-243在单侧黑质损伤大鼠中诱导的对侧转圈行为，但减弱了选择性D2激动剂溴隐亭的作用。同样，D1拮抗剂SCH 23390倾向于增强溴隐亭的作用，但显著抑制CY 208-243诱导的转圈。混合性D1/D2拮抗剂氟奋乃静可有效减少由任一激动剂诱导的转圈行为，而匹莫齐特（D1/D2）仅抑制溴隐亭的作用。这些结果表明，CY 208-243和溴隐亭的作用是通过不同但相互作用的受体亚型介导的。